2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid

Base Information

Chemical Name:2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid
CAS No.:594844-27-6
Molecular Formula:C₂₅H₂₁F₃N₂O₄
Molecular Weight:470.448
Hs Code.:

Synonyms:2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid

Suppliers and Price of 2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid

There total 13 articles about 2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1350468-91-5
methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate

: 594844-27-6
2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid

Guidance literature:: methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 16h;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: diethyl 2-((2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetoxy)methyl)-2-phenylmalonate

: 594844-27-6
2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid

: 492-38-6
2-phenylacrylic acid

Guidance literature:: In aq. phosphate buffer; at 37 ℃; for 1h; pH=7.4; Enzymatic reaction;
DOI:10.1021/tx300243v

Reference yield:

: 480451-75-0
5-chloro-N,N-dimethyl-2-nitrobenzamide

: 594844-27-6
2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 3 h / 120 °C

2.1: hydrogenchloride; water / 3 h / Reflux

3.1: acetyl chloride / 3 h / 0 - 20 °C

4.1: hydrogen / 5%-palladium/activated carbon / toluene; tetrahydrofuran / 20 °C / 37503.8 Torr

5.1: triethylamine / 1,2-dichloro-ethane / 0.17 h / 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

With hydrogenchloride; water; hydrogen; sodium hydride; triethylamine; acetyl chloride; lithium hydroxide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;