rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Base Information

Chemical Name:rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one
CAS No.:1350523-43-1
Molecular Formula:C₁₂H₁₆N₄O
Molecular Weight:232.285
Hs Code.:

Synonyms:rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

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Technology Process of rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

There total 8 articles about rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1350523-42-0
rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one

: 1350523-43-1
rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In ethanol; ethyl acetate; at 20 ℃;

Reference yield:

: 1350523-41-9
rac-1,3-dimethyl-3-(3-nitrophenyl)-5-thioxopiperazine-2-one

: 1350523-43-1
rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / water; methanol / 4 h / 67 °C / sealed tube

2: hydrogen / 5%-palladium/activated carbon / ethyl acetate; ethanol / 20 °C

With ammonium hydroxide; hydrogen; 5%-palladium/activated carbon; In methanol; ethanol; water; ethyl acetate;

Reference yield:

: 1350523-71-5
2-(2-chloroacetylamino)-2-(3-nitrophenyl)propionic acid methyl ester

: 1350523-43-1
rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 3 h / 70 °C

2: Lawessons reagent; pyridine / toluene / 18 h / 90 °C

3: ammonia; water / methanol / 4 h / 67 °C

4: palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 12 h / 20 °C

With Lawessons reagent; pyridine; palladium on activated charcoal; ammonia; water; hydrogen; In methanol; ethanol; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2011.10.050