rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one

Base Information

Chemical Name:rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one
CAS No.:1350523-42-0
Molecular Formula:C₁₂H₁₄N₄O₃
Molecular Weight:262.268
Hs Code.:

Synonyms:rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one

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Chemical Property of rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one

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Technology Process of rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one

There total 7 articles about rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1350523-41-9
rac-1,3-dimethyl-3-(3-nitrophenyl)-5-thioxopiperazine-2-one

: 1350523-42-0
rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: With ammonium hydroxide; In methanol; water; at 67 ℃; for 4h; sealed tube;

Reference yield:

: 1350523-39-5
rac-2-amino-2-(3-nitro-phenyl)-propionic acid methyl ester

: 1350523-42-0
rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: ethanol / 3 h / 70 °C

3: Lawessons reagent; pyridine / toluene / 18 h / 90 °C

4: ammonia; water / methanol / 4 h / 67 °C

With Lawessons reagent; pyridine; ammonia; water; triethylamine; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2011.10.050

Reference yield:

: 954272-07-2
rac-2-amino-2-(3-nitro-phenyl)-propionitrile

: 1350523-42-0
rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; water / 18 h / Reflux

2.1: thionyl chloride / 0.25 h / 0 °C

2.2: 18 h / Reflux

3.1: triethylamine / dichloromethane / 1 h / 0 °C

4.1: ethanol / 3 h / 70 °C

5.1: Lawessons reagent; pyridine / toluene / 18 h / 90 °C

6.1: ammonia; water / methanol / 4 h / 67 °C

With Lawessons reagent; pyridine; hydrogenchloride; thionyl chloride; ammonia; water; triethylamine; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2011.10.050