rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide

Base Information

Chemical Name:rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide
CAS No.:1350523-59-9
Molecular Formula:C₁₈H₁₈ClN₅O₂
Molecular Weight:371.826
Hs Code.:

Synonyms:rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide

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Chemical Property of rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide

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Technology Process of rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide

There total 18 articles about rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 86873-60-1
5-chloropicolinic acid

: 1350523-43-1
rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

: 1350523-59-9
rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide

Guidance literature:: 5-chloropicolinic acid; rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one; With N,N-dimethyl-aniline; In dichloromethane; at 20 ℃; for 0.0833333h;

With HATU; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 6.0%

: 370104-72-6
5-chloropyridine-2-carboxamide

: 1352126-40-9
rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

: 1350523-59-9
rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide

Guidance literature:: With potassium phosphate; copper(l) iodide; trans-1,2-Diaminocyclohexane; In N,N-dimethyl-formamide; at 20 - 180 ℃; for 2.33333h; Microwave irradiation; Inert atmosphere; sealed tube;

Reference yield:

: 1350523-41-9
rac-1,3-dimethyl-3-(3-nitrophenyl)-5-thioxopiperazine-2-one

: 1350523-59-9
rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium hydroxide / water; methanol / 4 h / 67 °C / sealed tube

2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate; ethanol / 20 °C

3.1: N,N-dimethyl-aniline / dichloromethane / 0.08 h / 20 °C

3.2: 16 h / 20 °C

With ammonium hydroxide; hydrogen; N,N-dimethyl-aniline; 5%-palladium/activated carbon; In methanol; ethanol; dichloromethane; water; ethyl acetate;