2,3-dihydro-7-methoxy-1H-indene-1-spiro-2'-(3'-benzylidene-4',7'-dimethoxy-2H-inden-1'-one)

Base Information

Chemical Name:2,3-dihydro-7-methoxy-1H-indene-1-spiro-2'-(3'-benzylidene-4',7'-dimethoxy-2H-inden-1'-one)
CAS No.:107135-62-6
Molecular Formula:C₂₇H₂₄O₄
Molecular Weight:412.485
Hs Code.:

Synonyms:2,3-dihydro-7-methoxy-1H-indene-1-spiro-2'-(3'-benzylidene-4',7'-dimethoxy-2H-inden-1'-one)

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Chemical Property of 2,3-dihydro-7-methoxy-1H-indene-1-spiro-2'-(3'-benzylidene-4',7'-dimethoxy-2H-inden-1'-one)

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Technology Process of 2,3-dihydro-7-methoxy-1H-indene-1-spiro-2'-(3'-benzylidene-4',7'-dimethoxy-2H-inden-1'-one)

There total 12 articles about 2,3-dihydro-7-methoxy-1H-indene-1-spiro-2'-(3'-benzylidene-4',7'-dimethoxy-2H-inden-1'-one) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 107135-61-5
1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1-(phenylseleno)-1H-indene

: 107135-62-6
2,3-dihydro-7-methoxy-1H-indene-1-spiro-2'-(3'-benzylidene-4',7'-dimethoxy-2H-inden-1'-one)

Guidance literature:: With 2,2'-azobis(isobutyronitrile); triphenylstannane; In benzene; for 12h; Heating;
DOI:10.1021/jo00383a032

Reference yield:

: 13146-23-1
copper(I) phenylacetylenide

: 107135-62-6
2,3-dihydro-7-methoxy-1H-indene-1-spiro-2'-(3'-benzylidene-4',7'-dimethoxy-2H-inden-1'-one)

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / pyridine / 12 h / Heating

2: 1.) n-butyllithium / 1.) hexane, ether, -78 deg C, 20 min, 2.) hexane, ether, from -78 deg C to 0 deg C, 2 h

3: 75 percent / pyridinium chlorochromate, 3-A molecular sieves / CH₂Cl₂ / 4 h / Ambient temperature

4: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, from -78 deg C to -20 deg C, 1.5 h

5: 79 percent / triphenyltin hydride, AIBN / benzene / 12 h / Heating

With pyridine; n-butyllithium; 2,2'-azobis(isobutyronitrile); 3 A molecular sieve; triphenylstannane; pyridinium chlorochromate; lithium diisopropyl amide; In dichloromethane; benzene;
DOI:10.1021/jo00383a032

Reference yield:

: 34985-41-6
7-methoxy-indan-1-one

: 107135-62-6
2,3-dihydro-7-methoxy-1H-indene-1-spiro-2'-(3'-benzylidene-4',7'-dimethoxy-2H-inden-1'-one)

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) potassium tert-butoxide / 1.) dioxane, RT, 1.5 h, 2.) dioxane, RT, 22 h

2: p-toluenesulfonic acid monohydrate / dioxane; H₂O / 14 h / Heating

3: 1.) n-butyllithium / 1.) hexane, ether, -78 deg C, 20 min, 2.) hexane, ether, from -78 deg C to 0 deg C, 2 h

4: 75 percent / pyridinium chlorochromate, 3-A molecular sieves / CH₂Cl₂ / 4 h / Ambient temperature

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, from -78 deg C to -20 deg C, 1.5 h

6: 79 percent / triphenyltin hydride, AIBN / benzene / 12 h / Heating

With n-butyllithium; 2,2'-azobis(isobutyronitrile); 3 A molecular sieve; triphenylstannane; potassium tert-butylate; toluene-4-sulfonic acid; pyridinium chlorochromate; lithium diisopropyl amide; In 1,4-dioxane; dichloromethane; water; benzene;
DOI:10.1021/jo00383a032