3,6-Dimethoxy-2-nitroaniline

Base Information

• Chemical Name: 3,6-Dimethoxy-2-nitroaniline
• CAS No.: 26002-57-3
• Molecular Formula: C8H10N2O4
• Molecular Weight: 198.178
• Mol file: 26002-57-3.mol

Synonyms:3,6-Dimethoxy-2-nitroaniline

Chemical Property of 3,6-Dimethoxy-2-nitroaniline

Chemical Property:

• PSA: 90.30000
• LogP: 2.29860

Purity/Quality:

99% ^*data from raw suppliers

3,6-DIMETHOXY-2-NITRO-PHENYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6-Dimethoxy-2-nitroaniline

There total 10 articles about 3,6-Dimethoxy-2-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,4-dimethoxy-2,3-dinitrobenzene (6945-76-2) → 2-amino-3-nitrohydroquinone dimethylether (26002-57-3)

Guidance literature:

1,4-dimethoxy-2,3-dinitrobenzene; With iron(III) chloride hexahydrate; In methanol; at 65 ℃; for 1h;

With hydrazine hydrate; In methanol; at 65 ℃; for 1h;

DOI:10.1016/j.bioorg.2021.104823

Reference yield: 66.0%

1,4-dimethoxy-2-nitrobenzene (89-39-4) → 2,5-dimethoxy-4-nitroaniline (6313-37-7) + 2-amino-3-nitrohydroquinone dimethylether (26002-57-3)

Guidance literature:

1,4-dimethoxy-2-nitrobenzene; With pyridine; trifluorormethanesulfonic acid; lithium perchlorate; In acetonitrile; at 25 ℃; Electrochemical reaction;

With piperidine; In acetonitrile; at 80 ℃; for 12h; Overall yield = 95 %; Electrochemical reaction;

DOI:10.1021/ja402083e

Reference yield:

pyridine (110-86-1) + 1,4-dimethoxy-2-nitrobenzene (89-39-4) → 2,5-dimethoxy-4-nitroaniline (6313-37-7) + 2-amino-3-nitrohydroquinone dimethylether (26002-57-3)

Guidance literature:

pyridine; 1,4-dimethoxy-2-nitrobenzene; With ammonium peroxydisulfate; tris(1,10-phenathrolinyl)ruthenium(II) hexafluorophosphate; In water; acetonitrile; at 23 ℃; for 24h; Irradiation; Inert atmosphere; Schlenk technique;

With pyrrolidine; at 70 ℃; for 12h;

DOI:10.1021/acs.orglett.0c00822

upstream raw materials:

2,5-dimethoxy-6-nitrobenzamide

2,5-dimethoxybenzoic acid

2,5-dihydroxybenzoic acid.

2,5-dimethoxybenzamide

Downstream raw materials:

Ethyl-2-cyano-2-(3,6-dimethoxy-2-nitrophenyl)-azoacetat

Diethyl-(3,6-dimethoxy-2-nitrophenyl)-azomalonat

N-(3,6-Dimethoxy-2-nitro)phenylpyrrole

2-bromo-1,4-dimethoxy-3-nitrobenzene