(2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-5-formyl-4-methylpentyl acetate

Base Information

Chemical Name:(2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-5-formyl-4-methylpentyl acetate
CAS No.:1338481-42-7
Molecular Formula:C₂₅H₃₃NO₄
Molecular Weight:411.541
Hs Code.:

Synonyms:(2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-5-formyl-4-methylpentyl acetate

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Chemical Property of (2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-5-formyl-4-methylpentyl acetate

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Technology Process of (2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-5-formyl-4-methylpentyl acetate

There total 7 articles about (2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-5-formyl-4-methylpentyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1338481-41-6
(2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-6-hydroxy-4-methylhexyl acetate

: 1338481-42-7
(2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-5-formyl-4-methylpentyl acetate

Guidance literature:: (2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-6-hydroxy-4-methylhexyl acetate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.0833333h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.08.048

Reference yield:

: C₃₁H₃₈BNO₅

: 1338481-42-7
(2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-5-formyl-4-methylpentyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; methanol; water / 1 h / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.08 h / -78 °C / Inert atmosphere

2.2: -78 - 0 °C / Inert atmosphere

With oxalyl dichloride; dihydrogen peroxide; dimethyl sulfoxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 2.1: Swern oxidation / 2.2: Swern oxidation;
DOI:10.1016/j.tetlet.2011.08.048

Reference yield:

: 1338481-39-2
(2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-4-methylhex-5-en-1-yl acetate

: 1338481-42-7
(2R,3R,4R)-2-(N-methyl-N-((R)-1-phenylethyl)amino)-3-(benzyloxy)-5-formyl-4-methylpentyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Wilkinson's catalyst / tetrahydrofuran / 1.02 h / 0 °C / Inert atmosphere

2.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; methanol; water / 1 h / 0 - 20 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.08 h / -78 °C / Inert atmosphere

3.2: -78 - 0 °C / Inert atmosphere

With Wilkinson's catalyst; oxalyl dichloride; dihydrogen peroxide; dimethyl sulfoxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 3.1: Swern oxidation / 3.2: Swern oxidation;
DOI:10.1016/j.tetlet.2011.08.048