(R)-2-((1R,2R)-1-(benzyloxy)-2-methylbut-3-en-1-yl)-1-((R)-1-phenylethyl)aziridine

Base Information

Chemical Name:(R)-2-((1R,2R)-1-(benzyloxy)-2-methylbut-3-en-1-yl)-1-((R)-1-phenylethyl)aziridine
CAS No.:1338481-38-1
Molecular Formula:C₂₂H₂₇NO
Molecular Weight:321.462
Hs Code.:

Synonyms:(R)-2-((1R,2R)-1-(benzyloxy)-2-methylbut-3-en-1-yl)-1-((R)-1-phenylethyl)aziridine

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Chemical Property of (R)-2-((1R,2R)-1-(benzyloxy)-2-methylbut-3-en-1-yl)-1-((R)-1-phenylethyl)aziridine

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Technology Process of (R)-2-((1R,2R)-1-(benzyloxy)-2-methylbut-3-en-1-yl)-1-((R)-1-phenylethyl)aziridine

There total 3 articles about (R)-2-((1R,2R)-1-(benzyloxy)-2-methylbut-3-en-1-yl)-1-((R)-1-phenylethyl)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1338481-37-0
(1R,2R)-2-methyl-1-((R)-1-((R)-1-phenylethyl)aziridin-2-yl)but-3-en-1-ol

: 100-39-0
benzyl bromide

: 1338481-38-1
(R)-2-((1R,2R)-1-(benzyloxy)-2-methylbut-3-en-1-yl)-1-((R)-1-phenylethyl)aziridine

Guidance literature:: (1R,2R)-2-methyl-1-((R)-1-((R)-1-phenylethyl)aziridin-2-yl)but-3-en-1-ol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.08.048

Reference yield:

: C₂₅H₃₆BNO₇

: 1338481-38-1
(R)-2-((1R,2R)-1-(benzyloxy)-2-methylbut-3-en-1-yl)-1-((R)-1-phenylethyl)aziridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / toluene / 0.33 h / -78 - 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 3 h / 0 - 20 °C / Inert atmosphere

With water; sodium hydride; sodium hydroxide; In tetrahydrofuran; toluene; mineral oil;
DOI:10.1016/j.tetlet.2011.08.048

Reference yield:

: [1'(R)-α-methylbenzyl]aziridine-2(R)-carboxaldehyde

: 1338481-38-1
(R)-2-((1R,2R)-1-(benzyloxy)-2-methylbut-3-en-1-yl)-1-((R)-1-phenylethyl)aziridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 3.5 h / -78 °C / Inert atmosphere; Molecular sieve

2.1: water; sodium hydroxide / toluene / 0.33 h / -78 - 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 3 h / 0 - 20 °C / Inert atmosphere

With water; sodium hydride; sodium hydroxide; In tetrahydrofuran; toluene; mineral oil;
DOI:10.1016/j.tetlet.2011.08.048