2-{[4-({butyl[2-chloro-4'-(trifluoromethyl)-3-biphenylyl]amino}sulfonyl)-2,3-dimethylphenyl]oxy}propanoic acid

Base Information

Chemical Name:2-{[4-({butyl[2-chloro-4'-(trifluoromethyl)-3-biphenylyl]amino}sulfonyl)-2,3-dimethylphenyl]oxy}propanoic acid
CAS No.:1304582-39-5
Molecular Formula:C₂₈H₂₉ClF₃NO₅S
Molecular Weight:584.056
Hs Code.:

Synonyms:2-{[4-({butyl[2-chloro-4'-(trifluoromethyl)-3-biphenylyl]amino}sulfonyl)-2,3-dimethylphenyl]oxy}propanoic acid

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Chemical Property of 2-{[4-({butyl[2-chloro-4'-(trifluoromethyl)-3-biphenylyl]amino}sulfonyl)-2,3-dimethylphenyl]oxy}propanoic acid

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Technology Process of 2-{[4-({butyl[2-chloro-4'-(trifluoromethyl)-3-biphenylyl]amino}sulfonyl)-2,3-dimethylphenyl]oxy}propanoic acid

There total 6 articles about 2-{[4-({butyl[2-chloro-4'-(trifluoromethyl)-3-biphenylyl]amino}sulfonyl)-2,3-dimethylphenyl]oxy}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1304581-39-2
2-[(4-{[(3-bromo-2-chlorophenyl)(butyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoic acid

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1304582-39-5
2-{[4-({butyl[2-chloro-4'-(trifluoromethyl)-3-biphenylyl]amino}sulfonyl)-2,3-dimethylphenyl]oxy}propanoic acid

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate; In tetrahydrofuran; water; at 160 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1016/j.bmcl.2011.02.077

Reference yield:

: 1304581-32-5
methyl 2-{[4-(chlorosulfonyl)-2,3-dimethylphenyl]oxy}propanoate

: 1304582-39-5
2-{[4-({butyl[2-chloro-4'-(trifluoromethyl)-3-biphenylyl]amino}sulfonyl)-2,3-dimethylphenyl]oxy}propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 16 h

2: potassium carbonate / N,N-dimethyl-formamide / 0.12 h / 170 °C / Microwave irradiation

3: lithium hydroxide / ethyl acetate

4: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate / tetrahydrofuran; water / 0.17 h / 160 °C / Microwave irradiation

With pyridine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; caesium carbonate; lithium hydroxide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.02.077

Reference yield:

: 1304581-36-9
methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate

: 1304582-39-5
2-{[4-({butyl[2-chloro-4'-(trifluoromethyl)-3-biphenylyl]amino}sulfonyl)-2,3-dimethylphenyl]oxy}propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.12 h / 170 °C / Microwave irradiation

2: lithium hydroxide / ethyl acetate

3: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate / tetrahydrofuran; water / 0.17 h / 160 °C / Microwave irradiation

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; caesium carbonate; lithium hydroxide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.02.077