C₂₁H₂₀F₃N₃O

Base Information

Chemical Name:C₂₁H₂₀F₃N₃O
CAS No.:1353554-88-7
Molecular Formula:C₂₁H₂₀F₃N₃O
Molecular Weight:387.405
Hs Code.:

C<sub>21</sub>H<sub>20</sub>F<sub>3</sub>N<sub>3</sub>O

Synonyms:C₂₁H₂₀F₃N₃O

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Chemical Property of C₂₁H₂₀F₃N₃O

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Technology Process of C₂₁H₂₀F₃N₃O

There total 7 articles about C₂₁H₂₀F₃N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1353556-02-1
1,3-di-Boc-2-(2-(5-(2-methoxy-4-(trifluoromethyl)phenyl)naphthalen-1-yl)ethyl)guanidine

: 1353554-88-7
C₂₁H₂₀F₃N₃O

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

: 20366-57-8
(5-bromo-naphthalen-1-yl)-methanol

: 1353554-88-7
C₂₁H₂₀F₃N₃O

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / palladium diacetate; XPhos / 1,4-dioxane; water / 2 h / 100 °C

2.1: triethylamine / dichloromethane / 20 °C

3.1: N,N-dimethyl-formamide / 20 °C

4.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 20 °C

4.2: pH > 9 / Cooling with ice

5.1: triethylamine / dichloromethane / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; trifluoroacetic acid; palladium diacetate; XPhos; In 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;

Reference yield:

: 41498-06-0
5-bromo-1-naphthaldehyde

: 1353554-88-7
C₂₁H₂₀F₃N₃O

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / ethanol / 0.5 h / 20 °C

2.1: potassium carbonate / palladium diacetate; XPhos / 1,4-dioxane; water / 2 h / 100 °C

3.1: triethylamine / dichloromethane / 20 °C

4.1: N,N-dimethyl-formamide / 20 °C

5.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 20 °C

5.2: pH > 9 / Cooling with ice

6.1: triethylamine / dichloromethane / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; lithium aluminium tetrahydride; potassium carbonate; triethylamine; trifluoroacetic acid; palladium diacetate; XPhos; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;