4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine
CAS No.:942920-82-3
Molecular Formula:C₂₄H₂₂BrN₃O₃S
Molecular Weight:512.427
Hs Code.:

Synonyms:4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine

There total 5 articles about 4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 889939-26-8
4-bromo-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 279262-23-6
[4-(morpholin-4-ylmethyl)phenyl]boronic acid

: 942920-82-3
4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm901870q

Reference yield:

: C₁₃H₈Br₂N₂O₂S

: 279262-23-6
[4-(morpholin-4-ylmethyl)phenyl]boronic acid

: 942920-82-3
4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; at 80 ℃;
DOI:10.1016/j.bmc.2015.06.023

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 942920-82-3
4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 4 h / 20 °C

2: lithium diisopropyl amide; 1,2-dibromo-1,1,2,2-tetrachloroethane / tetrahydrofuran / 3 h / -78 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane / 80 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,2-dibromo-1,1,2,2-tetrachloroethane; potassium tert-butylate; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; 3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2015.06.023