889939-26-8

Basic information

• Product Name: 4-BROMO-2-IODO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 4-BROMO-2-IODO-1-BENZENSULFONYL-7-AZAINDOLE;4-BROMO-2-IODO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE;N-Tosyl-4-bromo-3-iodo-7-azaindole;1-(Phenylsulfonyl)-4-bromo-2-iodo-7-azaindole;1H-Pyrrolo[2,3-b]pyridine, 4-broMo-2-iodo-1-(phenylsulfonyl)-;1-(Phenylsulphonyl)-4-broMo-2-iodo-7-azaindole;1-(benzenesulfonyl)-4-bromo-2-iodo-1H-pyrrolo[2,3-b]pyridine;1-(benzenesulfonyl)-4-bromo-2-iodopyrrolo[2,3-b]pyridine
• CAS NO: 889939-26-8
• Molecular Formula: C₁₃H₈BrIN₂O₂S
• Molecular Weight: 463.09
• Mol File: 889939-26-8.mol

Chemical Properties

• Boiling Point: 572.196 °C at 760 mmHg
• Flash Point: 299.854 °C
• Appearance: /
• Density: 2.083g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.763
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-BROMO-2-IODO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-IODO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE(889939-26-8)
• EPA Substance Registry System: 4-BROMO-2-IODO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE(889939-26-8)

Safety Data

• Hazardous Substances Data: 889939-26-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-iodo-1-(phenylsulfonyl)pyrrolo[2,3-b]pyridine is used as a chemical intermediate for the development of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. This kinase inhibitor has potential applications in the treatment of various diseases, particularly those involving abnormal cell division and proliferation.

InChI:InChI=1/C13H8BrIN2O2S/c14-11-6-7-16-13-10(11)8-12(15)17(13)20(18,19)9-4-2-1-3-5-9/h1-8H

Upstream product

• 889939-25-7 1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine 
• 1260879-70-6 4-bromo-2-iodo-1H-pyrrolo[2,3-b]pyridine 
• 98-09-9 benzenesulfonyl chloride 
• 348640-06-2 4-bromo-7-azaindole 

Downstream Products

• 943324-29-6 4-bromo-2-(3-furanyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 942921-47-3 4-bromo-2-(3-formyl-6-methyl-phenyl)-1-phenylsulfonyl-1Hpyrrolo[2,3-b]pyridine 
• 942920-78-7 4-bromo-2-[4-(dimethylaminomethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine 
• 1227089-34-0 4-bromo-2-(4-formyl-6-methyl-phenyl)-1-phenylsulfonyl-1Hpyrrolo[2,3-b]pyridine 
• 942920-73-2 N-{3-[4-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]phenyl}acetamide 
• 942920-70-9 N-{4-[4-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]phenyl}acetamide 
• 942920-82-3 4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine 
• 942920-20-9 tert-butyl 4-(4-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate 

Relevant articles and documents

COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES

The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases

TANK-BINDING KINASE INHIBITOR COMPOUNDS

Compounds having the following formula (I) and methods of their use and preparation are disclosed:

TETRACYCLIC CDK9 KINASE INHIBITORS

Disclosed are compounds of Formula (Ia), and pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R3A, R3B, and R4 are as described herein. The compounds may be used as agents in the treatment of diseases, including cancer. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula (Ia).