amino(3-(2-carboxy-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)phenyl)propylamino)methaniminium 2,2,2-trifluoroacetate

Base Information

Chemical Name:amino(3-(2-carboxy-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)phenyl)propylamino)methaniminium 2,2,2-trifluoroacetate
CAS No.:1239957-13-1
Molecular Formula:C₂HF₃O₂*C₃₁H₃₂Cl₂FN₅O₃S
Molecular Weight:758.621
Hs Code.:

amino(3-(2-carboxy-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)phenyl)propylamino)methaniminium 2,2,2-trifluoroacetate

Synonyms:amino(3-(2-carboxy-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)phenyl)propylamino)methaniminium 2,2,2-trifluoroacetate

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Chemical Property of amino(3-(2-carboxy-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)phenyl)propylamino)methaniminium 2,2,2-trifluoroacetate

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Technology Process of amino(3-(2-carboxy-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)phenyl)propylamino)methaniminium 2,2,2-trifluoroacetate

There total 7 articles about amino(3-(2-carboxy-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)phenyl)propylamino)methaniminium 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1239963-54-2
methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate

: 76-05-1
trifluoroacetic acid

: 1239957-13-1
amino(3-(2-carboxy-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)phenyl)propylamino)methaniminium 2,2,2-trifluoroacetate

Guidance literature:: methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate; With water; barium(II) hydroxide; In methanol; at 50 ℃; for 2.5h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 90721-58-7
methyl 2-bromo-5-(bromomethyl)benzoate

: 1239957-13-1
amino(3-(2-carboxy-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)phenyl)propylamino)methaniminium 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetone / 1 h / 20 °C

2: pyrrolidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 80 °C

3: hydrogen / platinum(IV) oxide / ethanol / 16 h / 20 °C / 3102.97 Torr

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h

5: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

6: water; barium(II) hydroxide / methanol / 2.5 h / 50 °C

With pyrrolidine; di-isopropyl azodicarboxylate; water; hydrogen; potassium carbonate; triphenylphosphine; trifluoroacetic acid; barium(II) hydroxide; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1239956-64-9
methyl 2-bromo-5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)benzoate

: 1239957-13-1
amino(3-(2-carboxy-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)phenyl)propylamino)methaniminium 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: pyrrolidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 80 °C

2: hydrogen / platinum(IV) oxide / ethanol / 16 h / 20 °C / 3102.97 Torr

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h

4: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

5: water; barium(II) hydroxide / methanol / 2.5 h / 50 °C

With pyrrolidine; di-isopropyl azodicarboxylate; water; hydrogen; triphenylphosphine; trifluoroacetic acid; barium(II) hydroxide; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;