methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate

Base Information

Chemical Name:methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate
CAS No.:1239963-54-2
Molecular Formula:C₃₂H₃₄Cl₂FN₅O₃S
Molecular Weight:658.624
Hs Code.:

Synonyms:methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate

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Chemical Property of methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate

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Technology Process of methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate

There total 6 articles about methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₂H₅₀Cl₂FN₅O₇S

: 1239963-54-2
methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 90721-58-7
methyl 2-bromo-5-(bromomethyl)benzoate

: 1239963-54-2
methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 1 h / 20 °C

2: pyrrolidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 80 °C

3: hydrogen / platinum(IV) oxide / ethanol / 16 h / 20 °C / 3102.97 Torr

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h

5: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With pyrrolidine; di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; trifluoroacetic acid; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1239956-64-9
methyl 2-bromo-5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)benzoate

: 1239963-54-2
methyl 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-2-(3-guanidinopropyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyrrolidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 80 °C

2: hydrogen / platinum(IV) oxide / ethanol / 16 h / 20 °C / 3102.97 Torr

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h

4: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With pyrrolidine; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; trifluoroacetic acid; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;