C₂₄H₂₅BrN₂O₇S

Base Information

• Chemical Name: C₂₄H₂₅BrN₂O₇S
• CAS No.: 244126-38-3
• Molecular Formula: C₂₄H₂₅BrN₂O₇S
• Molecular Weight: 565.442
• Mol file: 244126-38-3.mol

Synonyms:C₂₄H₂₅BrN₂O₇S

Chemical Property of C₂₄H₂₅BrN₂O₇S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₅BrN₂O₇S

There total 26 articles about C₂₄H₂₅BrN₂O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C24H27BrN2O7S → C24H25BrN2O7S (244126-38-3)

Guidance literature:

With lead(IV) acetate; In benzene; at 80 ℃;

DOI:10.1055/s-1999-3161

Reference yield:

toluene-4-sulfonamide (70-55-3) → C24H25BrN2O7S (244126-38-3)

Guidance literature:

Multi-step reaction with 19 steps

1.1: Cs₂CO₃ / dimethylformamide / 80 °C

2.1: Et₃N / CH₂Cl₂ / 0 °C

3.1: HCl; H₂O / Heating

3.2: 88 percent / SnCl₄ / CH₂Cl₂ / 20 °C

4.1: 91 percent / NaOH / methanol / 20 °C

5.1: 98 percent / imidazole / dimethylformamide / 20 °C

6.1: Mg / tetrahydrofuran / 20 °C

6.2: 91 percent / CuI / tetrahydrofuran / 0 - 20 °C

7.1: 96 percent / DMAP / acetonitrile / 20 °C

8.1: 98 percent / TBAF / tetrahydrofuran / 20 °C

9.1: pyridine / CH₂Cl₂ / 0 °C

10.1: LiN₃ / dimethylformamide / 80 °C

11.1: TMSBr / CH₂Cl₂ / 20 °C

12.1: TFA / CH₂Cl₂ / 20 °C

13.1: 89 percent / PyHBr₃ / CH₂Cl₂ / 20 °C

14.1: 88 percent / TFA; H₂O / 70 °C

15.1: 89 percent / K₂CO₃ / acetone / Heating

16.1: 87 percent / BCl₃ / CH₂Cl₂ / -78 - 0 °C

17.1: 82 percent / H₂ / Rh/C / ethyl acetate / 20 °C

18.1: 92 percent / molecular sieves 4 Angstroem; propylene oxide / acetonitrile / 80 °C

19.1: 80 percent / Pb(OAc)4 / benzene / 80 °C

With pyridine; 1H-imidazole; lead(IV) acetate; hydrogenchloride; dmap; sodium hydroxide; lithium azide; trimethylsilyl bromide; 4 A molecular sieve; tetrabutyl ammonium fluoride; water; hydrogen; boron trichloride; potassium carbonate; caesium carbonate; magnesium; pyridinium hydrobromide perbromide; triethylamine; trifluoroacetic acid; methyloxirane; Rh on carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 1.1: Ring cleavage / 2.1: Substitution / 3.1: Substitution / 3.2: Isomerization / 4.1: Cyclization / 5.1: Substitution / 6.1: Metallation / 6.2: Substitution / 7.1: Substitution / 8.1: Substitution / 9.1: Substitution / 10.1: Substitution / 11.1: Substitution / 12.1: Substitution / 13.1: Bromination / 14.1: Cyclization / 15.1: Methylation / 16.1: Substitution / 17.1: Hydrogenolysis / 18.1: Cyclization / 19.1: Oxidation;

DOI:10.1055/s-1999-3161

Reference yield:

3-methylbenzene-1,2-diol (488-17-5) → C24H25BrN2O7S (244126-38-3)

Guidance literature:

Multi-step reaction with 19 steps

1.1: 83 percent / TEA / CH₂Cl₂ / 0 °C

2.1: 97 percent / Br₂; AcOH / CH₂Cl₂ / 20 °C

3.1: 96 percent / K₂CO₃ / acetone / Heating

4.1: 97 percent / H₂O; NaOH / ethanol / Heating

5.1: 97 percent / (i-Pr)2NEt / CH₂Cl₂ / 20 °C

6.1: Mg / tetrahydrofuran / 20 °C

6.2: 91 percent / CuI / tetrahydrofuran / 0 - 20 °C

7.1: 96 percent / DMAP / acetonitrile / 20 °C

8.1: 98 percent / TBAF / tetrahydrofuran / 20 °C

9.1: pyridine / CH₂Cl₂ / 0 °C

10.1: LiN₃ / dimethylformamide / 80 °C

11.1: TMSBr / CH₂Cl₂ / 20 °C

12.1: TFA / CH₂Cl₂ / 20 °C

13.1: 89 percent / PyHBr₃ / CH₂Cl₂ / 20 °C

14.1: 88 percent / TFA; H₂O / 70 °C

15.1: 89 percent / K₂CO₃ / acetone / Heating

16.1: 87 percent / BCl₃ / CH₂Cl₂ / -78 - 0 °C

17.1: 82 percent / H₂ / Rh/C / ethyl acetate / 20 °C

18.1: 92 percent / molecular sieves 4 Angstroem; propylene oxide / acetonitrile / 80 °C

19.1: 80 percent / Pb(OAc)4 / benzene / 80 °C

With pyridine; lead(IV) acetate; dmap; sodium hydroxide; lithium azide; trimethylsilyl bromide; 4 A molecular sieve; TEA; tetrabutyl ammonium fluoride; water; hydrogen; bromine; boron trichloride; potassium carbonate; magnesium; acetic acid; pyridinium hydrobromide perbromide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; methyloxirane; Rh on carbon; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 1.1: Tosylation / 2.1: Bromination / 3.1: Methylation / 4.1: Hydrolysis / 5.1: Etherification / 6.1: Metallation / 6.2: Substitution / 7.1: Substitution / 8.1: Substitution / 9.1: Substitution / 10.1: Substitution / 11.1: Substitution / 12.1: Substitution / 13.1: Bromination / 14.1: Cyclization / 15.1: Methylation / 16.1: Substitution / 17.1: Hydrogenolysis / 18.1: Cyclization / 19.1: Oxidation;

DOI:10.1055/s-1999-3161

upstream raw materials:

toluene-4-sulfonamide

3-methylbenzene-1,2-diol

5-bromo-2-methoxy-3-methyl-phenol

5-bromo-2-methoxy-1-methoxymethoxy-3-methyl-benzene