(R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

Base Information

Chemical Name:(R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide
CAS No.:1428796-07-9
Molecular Formula:C₃₆H₃₁FN₄O₃
Molecular Weight:586.666
Hs Code.:

Synonyms:(R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

Suppliers and Price of (R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

There total 13 articles about (R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90151-40-9
4-amino-3-methoxybenzaldehyde

: 1428796-07-9
(R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-Butyl nitrite; copper(I) bromide / acetonitrile / 18 h / 20 °C

2.1: ammonium acetate; acetic acid / 18 h / 80 °C

3.1: sodium tetrahydroborate; borane-THF / tetrahydrofuran / 18 h / 0 - 65 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

5.1: trichlorophosphate / toluene / 2 h / 110 °C

6.1: potassium carbonate; triethylamine / acetonitrile / 2 h / 100 °C

7.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 1.75 h / 85 °C / Inert atmosphere; Sealed tube

8.1: water; sodium hydroxide / ethanol / 3 h / 75 °C

8.2: pH 1

9.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h

10.1: palladium diacetate; caesium carbonate; triphenylphosphine / 1,4-dioxane / 22.5 h / Inert atmosphere; Sealed tube

10.2: 2 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; borane-THF; n-Butyl nitrite; ammonium acetate; water; palladium diacetate; potassium carbonate; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; copper(I) bromide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1121-86-4
1-Fluoro-3-iodobenzene

: 1428796-78-4
(R)-N-(1-(tert-butyldimethylsilyloxy)-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

: 1428796-07-9
(R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

Guidance literature:: 1-Fluoro-3-iodobenzene; (R)-N-(1-(tert-butyldimethylsilyloxy)-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide; With palladium diacetate; caesium carbonate; triphenylphosphine; In 1,4-dioxane; for 22.5h; Inert atmosphere; Sealed tube;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h;

Reference yield:

: 80410-57-7
3-methoxy-4-nitrobenzaldehyde

: 1428796-07-9
(R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: iron; ammonium chloride / ethanol; water / 2 h / 78 °C

2.1: n-Butyl nitrite; copper(I) bromide / acetonitrile / 18 h / 20 °C

3.1: ammonium acetate; acetic acid / 18 h / 80 °C

4.1: sodium tetrahydroborate; borane-THF / tetrahydrofuran / 18 h / 0 - 65 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

6.1: trichlorophosphate / toluene / 2 h / 110 °C

7.1: potassium carbonate; triethylamine / acetonitrile / 2 h / 100 °C

8.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 1.75 h / 85 °C / Inert atmosphere; Sealed tube

9.1: water; sodium hydroxide / ethanol / 3 h / 75 °C

9.2: pH 1

10.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h

11.1: palladium diacetate; caesium carbonate; triphenylphosphine / 1,4-dioxane / 22.5 h / Inert atmosphere; Sealed tube

11.2: 2 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; borane-THF; n-Butyl nitrite; ammonium acetate; water; palladium diacetate; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; copper(I) bromide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;