ethyl 3,3-bis(4-fluorophenyl)-2-(2-methyl-1H-tetrazol-5-yl)-2-propenoate

Base Information

Chemical Name:ethyl 3,3-bis(4-fluorophenyl)-2-(2-methyl-1H-tetrazol-5-yl)-2-propenoate
CAS No.:118875-21-1
Molecular Formula:C₁₉H₁₆F₂N₄O₂
Molecular Weight:370.358
Hs Code.:

Synonyms:ethyl 3,3-bis(4-fluorophenyl)-2-(2-methyl-1H-tetrazol-5-yl)-2-propenoate

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Chemical Property of ethyl 3,3-bis(4-fluorophenyl)-2-(2-methyl-1H-tetrazol-5-yl)-2-propenoate

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Technology Process of ethyl 3,3-bis(4-fluorophenyl)-2-(2-methyl-1H-tetrazol-5-yl)-2-propenoate

There total 5 articles about ethyl 3,3-bis(4-fluorophenyl)-2-(2-methyl-1H-tetrazol-5-yl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 118875-19-7
ethyl 3,3-bis(4-fluorophenyl)-2-(1H-tetrazol-5-yl)-2-propenoate

: 74-88-4
methyl iodide

: 118875-21-1
ethyl 3,3-bis(4-fluorophenyl)-2-(2-methyl-1H-tetrazol-5-yl)-2-propenoate

: 118875-20-0
ethyl 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoate

Guidance literature:: With sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm00129a004

Reference yield:

: 118875-18-6
ethyl 2-cyano-3,3-bis(4-fluorophenyl)-2-propenoate

: 118875-21-1
ethyl 3,3-bis(4-fluorophenyl)-2-(2-methyl-1H-tetrazol-5-yl)-2-propenoate

Guidance literature:: Multi-step reaction with 2 steps

1: tri-n-butyltin azide / 110 - 120 °C

2: NaH / tetrahydrofuran

With tri-n-butyltin azide; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm00129a004

Reference yield:

: 345-92-6
4,4'-Difluorobenzophenone

: 118875-21-1
ethyl 3,3-bis(4-fluorophenyl)-2-(2-methyl-1H-tetrazol-5-yl)-2-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / β-alanine, HOAc / benzene

2: tri-n-butyltin azide / 110 - 120 °C

3: NaH / tetrahydrofuran

With tri-n-butyltin azide; sodium hydride; acetic acid; 3-amino propanoic acid; In tetrahydrofuran; benzene;
DOI:10.1021/jm00129a004