ethyl 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoate

Base Information

• Chemical Name: ethyl 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoate
• CAS No.: 118875-20-0
• Molecular Formula: C₁₉H₁₆F₂N₄O₂
• Molecular Weight: 370.358
• Mol file: 118875-20-0.mol

Synonyms:ethyl 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoate

Chemical Property of ethyl 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoate

There total 7 articles about ethyl 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

ethyl 3,3-bis(4-fluorophenyl)-2-(1H-tetrazol-5-yl)-2-propenoate (118875-19-7) + methyl iodide (74-88-4) → ethyl 3,3-bis(4-fluorophenyl)-2-(2-methyl-1H-tetrazol-5-yl)-2-propenoate (118875-21-1) + ethyl 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoate (118875-20-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1021/jm00129a004

Reference yield:

4,4'-Difluorobenzophenone (345-92-6) + ethyl 2-(1-methyl-1H-tetrazol-5-yl)acetate (5250-25-9) → ethyl 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoate (118875-20-0)

Guidance literature:

With pyridine; titanium tetrachloride; In tetrahydrofuran; tetrachloromethane; 1.) -78 deg C, 15 min, 2.) RT, 24 h;

DOI:10.1021/jm00173a013

Reference yield:

ethyl 1-methyl-5-tetrazolyacetate + 4,4'-Difluorobenzophenone (345-92-6) → ethyl 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoate (118875-20-0)

Guidance literature:

titanium tetrachloride; In tetrahydrofuran; pyridine; tetrachloromethane;

upstream raw materials:

4,4'-Difluorobenzophenone

ethyl 2-(1-methyl-1H-tetrazol-5-yl)acetate

ethyl 3,3-bis(4-fluorophenyl)-2-(1H-tetrazol-5-yl)-2-propenoate

methyl iodide

Downstream raw materials:

3,3-Bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoyl chloride

3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenol