1-[(E)-2-Benzenesulfonyl-3-(2,2-dimethyl-propionyloxy)-allyl]-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:1-[(E)-2-Benzenesulfonyl-3-(2,2-dimethyl-propionyloxy)-allyl]-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester
CAS No.:848779-06-6
Molecular Formula:C₂₅H₃₄O₇S
Molecular Weight:478.607
Hs Code.:

Synonyms:1-[(E)-2-Benzenesulfonyl-3-(2,2-dimethyl-propionyloxy)-allyl]-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester

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Chemical Property of 1-[(E)-2-Benzenesulfonyl-3-(2,2-dimethyl-propionyloxy)-allyl]-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester

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Technology Process of 1-[(E)-2-Benzenesulfonyl-3-(2,2-dimethyl-propionyloxy)-allyl]-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester

There total 5 articles about 1-[(E)-2-Benzenesulfonyl-3-(2,2-dimethyl-propionyloxy)-allyl]-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 848778-97-2
1-((E)-3-Acetoxy-2-benzenesulfonyl-allyl)-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester

: 3282-30-2
pivaloyl chloride

: 848779-06-6
1-[(E)-2-Benzenesulfonyl-3-(2,2-dimethyl-propionyloxy)-allyl]-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: 1-((E)-3-Acetoxy-2-benzenesulfonyl-allyl)-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 1h;

pivaloyl chloride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/j.tet.2004.12.044

Reference yield:

: acetic acid 1-acetoxy-3-chloro-2-phenylsulfanyl-propyl ester

: 848779-06-6
1-[(E)-2-Benzenesulfonyl-3-(2,2-dimethyl-propionyloxy)-allyl]-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: m-chloroperbenzoic acid / CH₂Cl₂ / 0.33 h

2.1: diisopropylethylamine / CH₂Cl₂ / 2 h / 0 °C

3.1: sodium hydride / tetrahydrofuran / 0.33 h

3.2: 71 percent / tetrahydrofuran / 1 h

4.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 0 °C

4.2: 80 percent / tetrahydrofuran / 0 °C

With potassium tert-butylate; sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 3.2: Michael addition;
DOI:10.1016/j.tet.2004.12.044

Reference yield:

: 848778-96-1
acetic acid 1-acetoxy-2-benzenesulfonyl-allyl ester

: 848779-06-6
1-[(E)-2-Benzenesulfonyl-3-(2,2-dimethyl-propionyloxy)-allyl]-2,2,5-trimethyl-6-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h

1.2: 71 percent / tetrahydrofuran / 1 h

2.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 0 °C

2.2: 80 percent / tetrahydrofuran / 0 °C

With potassium tert-butylate; sodium hydride; In tetrahydrofuran; 1.2: Michael addition;
DOI:10.1016/j.tet.2004.12.044