2-(((1r,4r)-4-((3-benzhydryl-1,3-dimethylureido)methyl)cyclohexyl)methoxy)acetic acid

Base Information

Chemical Name:2-(((1r,4r)-4-((3-benzhydryl-1,3-dimethylureido)methyl)cyclohexyl)methoxy)acetic acid
CAS No.:1187857-66-4
Molecular Formula:C₂₆H₃₄N₂O₄
Molecular Weight:438.567
Hs Code.:

Synonyms:2-(((1r,4r)-4-((3-benzhydryl-1,3-dimethylureido)methyl)cyclohexyl)methoxy)acetic acid

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Chemical Property of 2-(((1r,4r)-4-((3-benzhydryl-1,3-dimethylureido)methyl)cyclohexyl)methoxy)acetic acid

Chemical Property:

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Technology Process of 2-(((1r,4r)-4-((3-benzhydryl-1,3-dimethylureido)methyl)cyclohexyl)methoxy)acetic acid

There total 4 articles about 2-(((1r,4r)-4-((3-benzhydryl-1,3-dimethylureido)methyl)cyclohexyl)methoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₄₂N₂O₄

: 1187857-66-4
2-(((1r,4r)-4-((3-benzhydryl-1,3-dimethylureido)methyl)cyclohexyl)methoxy)acetic acid

Guidance literature:: C₃₀H₄₂N₂O₄; With water; lithium hydroxide; at 65 ℃; for 2h;

With hydrogenchloride; water; pH=4;

Reference yield:

: 1187857-68-6
benzhydryl(methyl)carbamic chloride

: 1187857-66-4
2-(((1r,4r)-4-((3-benzhydryl-1,3-dimethylureido)methyl)cyclohexyl)methoxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2 h / 80 °C / microwave irradiation

2.1: rhodium(II) acetate / dichloromethane / 96 h / 20 °C

3.1: water; lithium hydroxide / 2 h / 65 °C

3.2: pH 4

With water; triethylamine; lithium hydroxide; rhodium(II) acetate; In dichloromethane;

Reference yield:

: 1187857-67-5
1-benzhydryl-3-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl)-1,3-dimethylurea

: 1187857-66-4
2-(((1r,4r)-4-((3-benzhydryl-1,3-dimethylureido)methyl)cyclohexyl)methoxy)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: rhodium(II) acetate / dichloromethane / 96 h / 20 °C

2.1: water; lithium hydroxide / 2 h / 65 °C

2.2: pH 4

With water; lithium hydroxide; rhodium(II) acetate; In dichloromethane;