benzhydryl(methyl)carbamic chloride

Base Information

• Chemical Name: benzhydryl(methyl)carbamic chloride
• CAS No.: 1187857-68-6
• Molecular Formula: C₁₅H₁₄ClNO
• Molecular Weight: 259.735
• Mol file: 1187857-68-6.mol

Synonyms:benzhydryl(methyl)carbamic chloride

Chemical Property of benzhydryl(methyl)carbamic chloride

Chemical Property:

Purity/Quality:

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Technology Process of benzhydryl(methyl)carbamic chloride

There total 1 articles about benzhydryl(methyl)carbamic chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + N-(diphenylmethyl)methylamine (14683-47-7) → benzhydryl(methyl)carbamic chloride (1187857-68-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h;

DOI:10.1016/j.tet.2019.03.038

Reference yield:

benzhydryl(methyl)carbamic chloride (1187857-68-6) → C15H13NO + C15H13NO

Guidance literature:

With carbon monoxide; (R)-AntPhos; palladium diacetate; caesium carbonate; Trimethylacetic acid; In toluene; at 80 ℃; for 24h; under 6840.46 Torr; Reagent/catalyst; Temperature; enantioselective reaction; Glovebox; Autoclave;

DOI:10.1016/j.tet.2019.03.038

Reference yield:

benzhydryl(methyl)carbamic chloride (1187857-68-6) + ((1r,4r)-4-((methylamino)methyl)cyclohexyl)methanol (554453-93-9) → 1-benzhydryl-3-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl)-1,3-dimethylurea (1187857-67-5)

Guidance literature:

With triethylamine; In dichloromethane; at 80 ℃; for 2h; microwave irradiation;

upstream raw materials:

bis(trichloromethyl) carbonate

N-(diphenylmethyl)methylamine

Downstream raw materials:

1-benzhydryl-3-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl)-1,3-dimethylurea

2-(((1r,4r)-4-((3-benzhydryl-1,3-dimethylureido)methyl)cyclohexyl)methoxy)acetic acid