cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

Base Information

Chemical Name:cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole
CAS No.:218161-96-7
Molecular Formula:C₂₁H₂₁FN₄O₄S
Molecular Weight:444.487
Hs Code.:

Synonyms:cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

Suppliers and Price of cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

There total 4 articles about cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 17872-55-8
3-hydroxy-2-hydroxymethyl-2-methylpropionic acid methyl ester

: 218162-49-3
2-dimethoxymethyl-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

: 2-carboxaldehyde-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

: 218161-94-5
trans-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

: 218161-96-7
cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

Guidance literature:: With toluene-4-sulfonic acid; trimethyl orthoformate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;
DOI:10.1021/jm011132l

Reference yield:

: 403-33-8
methyl 4-flurobenzoate

: 218161-96-7
cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / 0 °C

1.2: 99 percent / tetrahydrofuran / 3 h / 20 °C

2.1: 82 percent / 48percent HBr; DMSO / 3 h / 55 °C

3.1: 86 percent / NH₄OAc / methanol; various solvent(s) / 4 h / 20 °C

4.1: 36 percent / TsOH; CH(OMe)3 / dimethylformamide / 4 h / 80 °C

With ammonium acetate; sodium hexamethyldisilazane; toluene-4-sulfonic acid; dimethyl sulfoxide; trimethyl orthoformate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm011132l

Reference yield:

: 217661-99-9
1-(4-fluorophenyl)-2-(2-methylsulphanylpyrimidin-4-yl)-1-ethanone

: 218161-96-7
cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 48percent HBr; DMSO / 3 h / 55 °C

2: 86 percent / NH₄OAc / methanol; various solvent(s) / 4 h / 20 °C

3: 36 percent / TsOH; CH(OMe)3 / dimethylformamide / 4 h / 80 °C

With ammonium acetate; toluene-4-sulfonic acid; dimethyl sulfoxide; trimethyl orthoformate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm011132l