cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfonylpyrimidin-4-yl)-1H-imidazole

Base Information

Chemical Name:cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfonylpyrimidin-4-yl)-1H-imidazole
CAS No.:218162-34-6
Molecular Formula:C₂₁H₂₁FN₄O₆S
Molecular Weight:476.485
Hs Code.:

Synonyms:cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfonylpyrimidin-4-yl)-1H-imidazole

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Chemical Property of cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfonylpyrimidin-4-yl)-1H-imidazole

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Technology Process of cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfonylpyrimidin-4-yl)-1H-imidazole

There total 5 articles about cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfonylpyrimidin-4-yl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 218161-96-7
cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazole

: 218162-34-6
cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfonylpyrimidin-4-yl)-1H-imidazole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; for 16h;
DOI:10.1021/jm011132l

Reference yield:

: 403-33-8
methyl 4-flurobenzoate

: 218162-34-6
cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfonylpyrimidin-4-yl)-1H-imidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / 0 °C

1.2: 99 percent / tetrahydrofuran / 3 h / 20 °C

2.1: 82 percent / 48percent HBr; DMSO / 3 h / 55 °C

3.1: 86 percent / NH₄OAc / methanol; various solvent(s) / 4 h / 20 °C

4.1: 36 percent / TsOH; CH(OMe)3 / dimethylformamide / 4 h / 80 °C

5.1: 82 percent / mCPBA / CH₂Cl₂; methanol / 16 h

With ammonium acetate; sodium hexamethyldisilazane; toluene-4-sulfonic acid; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; trimethyl orthoformate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011132l

Reference yield:

: 217661-99-9
1-(4-fluorophenyl)-2-(2-methylsulphanylpyrimidin-4-yl)-1-ethanone

: 218162-34-6
cis-2-(5-methyl-5-carboxymethyl-1,3-dioxan-2-yl)-4-(4-fluorophenyl)-5-(2-methylsulfonylpyrimidin-4-yl)-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / 48percent HBr; DMSO / 3 h / 55 °C

2: 86 percent / NH₄OAc / methanol; various solvent(s) / 4 h / 20 °C

3: 36 percent / TsOH; CH(OMe)3 / dimethylformamide / 4 h / 80 °C

4: 82 percent / mCPBA / CH₂Cl₂; methanol / 16 h

With ammonium acetate; toluene-4-sulfonic acid; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; trimethyl orthoformate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011132l