3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-7-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

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Chemical Name:3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-7-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol
CAS No.:911837-42-8
Molecular Formula:C₄₅H₇₄O₆Si₃
Molecular Weight:795.335
Hs Code.:

3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-6-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-7-(<i>tert</i>-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

Synonyms:3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-7-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

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Chemical Property of 3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-7-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

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Technology Process of 3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-7-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

There total 12 articles about 3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-7-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 911837-51-9
1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene

: 911837-42-8
3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-7-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

Guidance literature:: With hydrogen; nickel; In ethanol;
DOI:10.1016/j.tetlet.2006.06.173

Reference yield:

: 870091-89-7
(-)-(R)-4-benzyl-3-[(2R,3S)-5-(benzyloxy)-3-hydroxy-2-methylpentanoyl]-1,3-oxazolidin-2-one

: 911837-42-8
3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-7-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 12 steps

1: 95 percent / imidazole / dimethylformamide

2: 90 percent / NaBH₄ / tetrahydrofuran; H₂O

3: 96 percent / Bu₂BOTf; Et₃N

4: 93 percent / NaBH₄ / tetrahydrofuran; H₂O

5: 95 percent / CSA / CH₂Cl₂

6: 95 percent / DIBAL-H / CH₂Cl₂ / 0 °C

7: 95 percent / 4-DMAP; pyridine / CH₂Cl₂; dimethylformamide

8: 90 percent / OsO₄; NMO; NaIO₄ / 2-methyl-propan-2-ol; H₂O

9: 100 percent / NaBH₄ / methanol

10: 95 percent / imidazole / dimethylformamide

11: 90 percent / H₂ / Raney Nickel / ethanol

With pyridine; 1H-imidazole; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; hydrogen; diisobutylaluminium hydride; triethylamine; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3: Swern oxidation / 4: Evans aldol condensation;
DOI:10.1016/j.tetlet.2006.06.173

Reference yield:

: 872369-16-9
(?)-(2S,3S)-5-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2-methylpentan-1-ol

: 911837-42-8
3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-7-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 96 percent / Bu₂BOTf; Et₃N

2: 93 percent / NaBH₄ / tetrahydrofuran; H₂O

3: 95 percent / CSA / CH₂Cl₂

4: 95 percent / DIBAL-H / CH₂Cl₂ / 0 °C

5: 95 percent / 4-DMAP; pyridine / CH₂Cl₂; dimethylformamide

6: 90 percent / OsO₄; NMO; NaIO₄ / 2-methyl-propan-2-ol; H₂O

7: 100 percent / NaBH₄ / methanol

8: 95 percent / imidazole / dimethylformamide

9: 90 percent / H₂ / Raney Nickel / ethanol

With pyridine; 1H-imidazole; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; hydrogen; diisobutylaluminium hydride; triethylamine; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Swern oxidation / 2: Evans aldol condensation;
DOI:10.1016/j.tetlet.2006.06.173