1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene

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Chemical Name:1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene
CAS No.:911837-51-9
Molecular Formula:C₅₂H₈₀O₆Si₃
Molecular Weight:885.46
Hs Code.:

1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene

Synonyms:1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene

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Chemical Property of 1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene

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Technology Process of 1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene

There total 12 articles about 1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 911837-41-7
7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 911837-51-9
1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.06.173

Reference yield:

: 872369-16-9
(?)-(2S,3S)-5-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2-methylpentan-1-ol

: 911837-51-9
1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 9 steps

1: 96 percent / Bu₂BOTf; Et₃N

2: 93 percent / NaBH₄ / tetrahydrofuran; H₂O

3: 95 percent / CSA / CH₂Cl₂

4: 95 percent / DIBAL-H / CH₂Cl₂ / 0 °C

5: 95 percent / 4-DMAP; pyridine / CH₂Cl₂; dimethylformamide

6: 90 percent / OsO₄; NMO; NaIO₄ / 2-methyl-propan-2-ol; H₂O

7: 100 percent / NaBH₄ / methanol

8: 95 percent / imidazole / dimethylformamide

With pyridine; 1H-imidazole; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Swern oxidation / 2: Evans aldol condensation;
DOI:10.1016/j.tetlet.2006.06.173

Reference yield:

: 870091-89-7
(-)-(R)-4-benzyl-3-[(2R,3S)-5-(benzyloxy)-3-hydroxy-2-methylpentanoyl]-1,3-oxazolidin-2-one

: 911837-51-9
1-{(1R,2S,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-pentyloxymethyl}-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 11 steps

1: 95 percent / imidazole / dimethylformamide

2: 90 percent / NaBH₄ / tetrahydrofuran; H₂O

3: 96 percent / Bu₂BOTf; Et₃N

4: 93 percent / NaBH₄ / tetrahydrofuran; H₂O

5: 95 percent / CSA / CH₂Cl₂

6: 95 percent / DIBAL-H / CH₂Cl₂ / 0 °C

7: 95 percent / 4-DMAP; pyridine / CH₂Cl₂; dimethylformamide

8: 90 percent / OsO₄; NMO; NaIO₄ / 2-methyl-propan-2-ol; H₂O

9: 100 percent / NaBH₄ / methanol

10: 95 percent / imidazole / dimethylformamide

With pyridine; 1H-imidazole; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3: Swern oxidation / 4: Evans aldol condensation;
DOI:10.1016/j.tetlet.2006.06.173