methyl 4-phenyl-1-(4-(trifluoromethyl)phenyl)isoquinoline-3-carboxylate

Base Information

Chemical Name:methyl 4-phenyl-1-(4-(trifluoromethyl)phenyl)isoquinoline-3-carboxylate
CAS No.:1610565-54-2
Molecular Formula:C₂₄H₁₆F₃NO₂
Molecular Weight:407.392
Hs Code.:

Synonyms:methyl 4-phenyl-1-(4-(trifluoromethyl)phenyl)isoquinoline-3-carboxylate

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Chemical Property of methyl 4-phenyl-1-(4-(trifluoromethyl)phenyl)isoquinoline-3-carboxylate

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Technology Process of methyl 4-phenyl-1-(4-(trifluoromethyl)phenyl)isoquinoline-3-carboxylate

There total 4 articles about methyl 4-phenyl-1-(4-(trifluoromethyl)phenyl)isoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: bis(4-(trifluoromethyl)phenyl)iodonium tetrafluoroborate

: 76203-05-9
methyl 2-isocyano-3,3-diphenyl acrylate

: 1610565-54-2
methyl 4-phenyl-1-(4-(trifluoromethyl)phenyl)isoquinoline-3-carboxylate

Guidance literature:: With tris[2-phenylpyridinato-C²,N]iridium(III); sodium carbonate; In methanol; at 26 ℃; for 24h; Inert atmosphere; Irradiation;
DOI:10.1039/c4cc01122h

Reference yield: 79.0%

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 76203-05-9
methyl 2-isocyano-3,3-diphenyl acrylate

: 1610565-54-2
methyl 4-phenyl-1-(4-(trifluoromethyl)phenyl)isoquinoline-3-carboxylate

Guidance literature:: With oxygen; manganese(II) acetylacetonate dihydrate; In toluene; at 80 ℃; for 2h; Schlenk technique;
DOI:10.1039/c4cc06427e

Reference yield:

: 119-61-9
benzophenone

: 1610565-54-2
methyl 4-phenyl-1-(4-(trifluoromethyl)phenyl)isoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / mineral oil; tetrahydrofuran / 2 h / 20 °C

2: triethylamine; trichlorophosphate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3: tris[2-phenylpyridinato-C²,N]iridium(III); sodium carbonate / methanol / 24 h / 26 °C / Inert atmosphere; Irradiation

With tris[2-phenylpyridinato-C²,N]iridium(III); sodium hydride; sodium carbonate; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; mineral oil;
DOI:10.1039/c4cc01122h