2-Formylamino-3,3-diphenyl-acrylic acid methyl ester

Base Information

• Chemical Name: 2-Formylamino-3,3-diphenyl-acrylic acid methyl ester
• CAS No.: 76203-36-6
• Molecular Formula: C₁₇H₁₅NO₃
• Molecular Weight: 281.311
• Mol file: 76203-36-6.mol

Synonyms:2-Formylamino-3,3-diphenyl-acrylic acid methyl ester

Chemical Property of 2-Formylamino-3,3-diphenyl-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Formylamino-3,3-diphenyl-acrylic acid methyl ester

There total 1 articles about 2-Formylamino-3,3-diphenyl-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

benzophenone (119-61-9) + isocyanoacetic acid methyl ester (39687-95-1) → 2-Formylamino-3,3-diphenyl-acrylic acid methyl ester (76203-36-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; 1) 30 to 35 deg C, 2) RT, 2 h;

DOI:10.1248/cpb.28.2374

Reference yield: 93.0%

2-Formylamino-3,3-diphenyl-acrylic acid methyl ester (76203-36-6) → methyl 2-isocyano-3,3-diphenyl acrylate (76203-05-9)

Guidance literature:

With triethylamine; trichlorophosphate; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1248/cpb.28.2374

Reference yield:

2-Formylamino-3,3-diphenyl-acrylic acid methyl ester (76203-36-6) → methyl 1-(4-chlorophenyl)-4-phenylisoquinoline-3-carboxylate (1610565-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; trichlorophosphate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2: tris[2-phenylpyridinato-C²,N]iridium(III); sodium carbonate / methanol / 24 h / 26 °C / Inert atmosphere; Irradiation

With tris[2-phenylpyridinato-C²,N]iridium(III); sodium carbonate; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol;

DOI:10.1039/c4cc01122h

upstream raw materials:

benzophenone

isocyanoacetic acid methyl ester

Downstream raw materials:

methyl 2-isocyano-3,3-diphenyl acrylate

methyl 1,4-diphenylisoquinoline-3-carboxylate

methyl 1-mesityl-4-phenylisoquinoline-3-carboxylate

methyl 1-(4-tert-butylphenyl)-4-phenylisoquinoline-3-carboxylate