1-oxo-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid amide

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Chemical Name:1-oxo-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid amide
CAS No.:1518920-13-2
Molecular Formula:C₁₅H₁₀F₃N₃O₂
Molecular Weight:321.259
Hs Code.:

Synonyms:1-oxo-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid amide

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Chemical Property of 1-oxo-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid amide

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Technology Process of 1-oxo-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid amide

There total 5 articles about 1-oxo-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1518920-10-9
1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

: 1518920-13-2
1-oxo-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid amide

Guidance literature:: With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1518920-13-2
1-oxo-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: ammonium acetate; acetic acid / 130 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere; Sealed tube

3.2: 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium acetate; dihydrogen peroxide; potassium carbonate; acetic acid; lithium hydroxide; XPhos; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 934-07-6
5-bromo-1H-pyrrole-2-carboxylic acid methyl ester

: 1518920-13-2
1-oxo-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: ammonium acetate; acetic acid / 130 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere; Sealed tube

3.2: 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium acetate; dihydrogen peroxide; potassium carbonate; acetic acid; lithium hydroxide; XPhos; In tetrahydrofuran; water; N,N-dimethyl-formamide;