5-[3-(1,1-Dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-8-hydroxy-3,4-dihydro-1H-quinolin-2-one; compound with oxalic acid

Base Information

Chemical Name:5-[3-(1,1-Dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-8-hydroxy-3,4-dihydro-1H-quinolin-2-one; compound with oxalic acid
CAS No.:80090-22-8
Molecular Formula:C₂H₂O₄*C₂₂H₂₈N₂O₄
Molecular Weight:474.511
Hs Code.:

Synonyms:5-[3-(1,1-Dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-8-hydroxy-3,4-dihydro-1H-quinolin-2-one; compound with oxalic acid

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Chemical Property of 5-[3-(1,1-Dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-8-hydroxy-3,4-dihydro-1H-quinolin-2-one; compound with oxalic acid

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Technology Process of 5-[3-(1,1-Dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-8-hydroxy-3,4-dihydro-1H-quinolin-2-one; compound with oxalic acid

There total 4 articles about 5-[3-(1,1-Dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-8-hydroxy-3,4-dihydro-1H-quinolin-2-one; compound with oxalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 65008-44-8
8-Benzyloxy-5-[3-(1,1-dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-3,4-dihydro-1H-quinolin-2-one

: 144-62-7,97993-78-7
oxalic acid

: 80090-22-8
5-[3-(1,1-Dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-8-hydroxy-3,4-dihydro-1H-quinolin-2-one; compound with oxalic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; water; for 8h; Ambient temperature;
DOI:10.1248/cpb.29.2166

Reference yield:

: 59430-56-7
5,8-Dihydroxy-3,4-dihydro-2(1H)-quinolinone

: 80090-22-8
5-[3-(1,1-Dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-8-hydroxy-3,4-dihydro-1H-quinolin-2-one; compound with oxalic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / K₂CO₃ / acetone; H₂O / 4 h / Heating

2: 56 percent / K₂CO₃ / propan-2-ol / 5 h / 70 - 80 °C

3: 40 percent / methanol

4: 83 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 8 h / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; water; isopropyl alcohol; acetone;
DOI:10.1248/cpb.29.2166

Reference yield:

: 59826-16-3
8-(Benzyloxy)-5-hydroxy-3,4-dihydro-2(1H)-quinolinone

: 80090-22-8
5-[3-(1,1-Dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-8-hydroxy-3,4-dihydro-1H-quinolin-2-one; compound with oxalic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / K₂CO₃ / propan-2-ol / 5 h / 70 - 80 °C

2: 40 percent / methanol

3: 83 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 8 h / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; water; isopropyl alcohol;
DOI:10.1248/cpb.29.2166