tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate

Base Information

Chemical Name:tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate
CAS No.:1549812-18-1
Molecular Formula:C₁₈H₂₈N₄O₃
Molecular Weight:348.445
Hs Code.:

Synonyms:tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate

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Chemical Property of tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate

Chemical Property:

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Technology Process of tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate

There total 4 articles about tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1549812-10-3
1,1-dimethylethyl ((3R)-1-{[4-(methylamino)-3-nitrophenyl]carbonyl}-3-piperidinyl)carbamate

: 1549812-18-1
tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 24h;

Reference yield:

: 36242-50-9
4-methylamino-3-nitro-benzoic acid methyl ester

: 1549812-18-1
tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

1.2: pH Ca_. 5

2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: hydrogen; palladium on activated charcoal / ethanol / 24 h / 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 14719-83-6
methyl 3-nitro-4-chlorobenzoate

: 1549812-18-1
tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 70 - 90 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

2.2: pH Ca_. 5

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: hydrogen; palladium on activated charcoal / ethanol / 24 h / 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;