36242-50-9

Basic information

• Product Name: 2-(methylamino)-5-(methoxycarbonyl)-3-nitrobenzene
• Synonyms: 2-(methylamino)-5-(methoxycarbonyl)-3-nitrobenzene;Methyl 4-(methylamino)-3-nitrobenzoate
• CAS NO: 36242-50-9
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 210.1867
• Mol File: 36242-50-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 145 °C
• Boiling Point: 362.3±32.0 °C(Predicted)
• Appearance: /
• Density: 1.325±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -2.72±0.25(Predicted)
• CAS DataBase Reference: 2-(methylamino)-5-(methoxycarbonyl)-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(methylamino)-5-(methoxycarbonyl)-3-nitrobenzene(36242-50-9)
• EPA Substance Registry System: 2-(methylamino)-5-(methoxycarbonyl)-3-nitrobenzene(36242-50-9)

Safety Data

• Hazardous Substances Data: 36242-50-9(Hazardous Substances Data)

Usage

General Description

2-(methylamino)-5-(methoxycarbonyl)-3-nitrobenzene is a compound with a molecular formula of C9H10N2O4. It is also known as Tolmetin, and is commonly used as a nonsteroidal anti-inflammatory drug (NSAID) to reduce pain and inflammation caused by conditions such as arthritis. The chemical structure of 2-(methylamino)-5-(methoxycarbonyl)-3-nitrobenzene consists of a benzene ring with a nitro group and a methoxycarbonyl group attached to different carbon atoms, as well as a methylamino group attached to the benzene ring. Its pharmacological properties are attributed to its ability to inhibit the synthesis of prostaglandins, which are known to cause inflammation and pain.

Upstream product

• 3987-92-6 methyl 4-amino-3-nitrobenzoate 
• 77-78-1 dimethyl sulfate 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 14719-83-6 methyl 3-nitro-4-chlorobenzoate 
• 593-51-1 methylamine hydrochloride 
• 67-56-1 methanol 
• 41263-74-5 4-(methylamino)-3-nitrobenzoic acid 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 74-89-5 methylamine 
• 7664-93-9 sulfuric acid 
• 82080-46-4 4-(methoxycarbonyl)-2-nitro-N,N-dimethylaniline 
• 7697-37-2 nitric acid 
• 329-59-9 4-fluoro-3-nitro-benzoic acid methyl ester 

Downstream Products

• 396652-38-3 methyl 1-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate 
• 66630-73-7 1-methyl-2-phenyl-1H-benzo[d]imidazole-5-carboxylic acid 
• 131020-36-5 methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate 
• 90349-17-0 2-amino-1-methyl-1H-1,3-benzodiazole-5-carboxylic acid 
• 1258070-65-3 methyl 2-amino-1-methyl-1H-1,3-benzodiazole-5-carboxylate 
• 423768-38-1 1-methyl-1H-1,2,3-benzotriazole-5-carbonyl chloride 

Relevant articles and documents

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

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BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS

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