2-methyl-propane-2-sulfonic acid (2-hydroxy-3,3-diphenyl-hex-5-enyl)-amide

Base Information

• Chemical Name: 2-methyl-propane-2-sulfonic acid (2-hydroxy-3,3-diphenyl-hex-5-enyl)-amide
• CAS No.: 881840-71-7
• Molecular Formula: C₂₂H₂₉NO₃S
• Molecular Weight: 387.543
• Mol file: 881840-71-7.mol

Synonyms:2-methyl-propane-2-sulfonic acid (2-hydroxy-3,3-diphenyl-hex-5-enyl)-amide

Chemical Property of 2-methyl-propane-2-sulfonic acid (2-hydroxy-3,3-diphenyl-hex-5-enyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-propane-2-sulfonic acid (2-hydroxy-3,3-diphenyl-hex-5-enyl)-amide

There total 1 articles about 2-methyl-propane-2-sulfonic acid (2-hydroxy-3,3-diphenyl-hex-5-enyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butylsulfonamide (34813-49-5) + 2-(1,1-diphenylbut-3-enyl)oxirane (741676-59-5) → 2-methyl-propane-2-sulfonic acid (2-hydroxy-3,3-diphenyl-hex-5-enyl)-amide (881840-71-7)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In 1,4-dioxane; at 90 ℃; for 16h;

DOI:10.1021/ol060101n

Reference yield:

2-methyl-propane-2-sulfonic acid (2-hydroxy-3,3-diphenyl-hex-5-enyl)-amide (881840-71-7) + Methanesulfonic anhydride (7143-01-3) → methanesulfonic acid 1-[(2-methyl-propane-2-sulfonylamino)-methyl]-2,2-diphenyl-pent-4-enyl ester

Guidance literature:

With pyridine; dmap; In dichloromethane; for 0.75h;

DOI:10.1021/ol060101n

Reference yield:

2-methyl-propane-2-sulfonic acid (2-hydroxy-3,3-diphenyl-hex-5-enyl)-amide (881840-71-7) → 1-(tert-butylsulfonyl)-2-(1,1-diphenylbut-3-enyl)aziridine (881840-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; 4-dimethylaminopyridine / CH₂Cl₂ / 0.75 h

2: 2.00 g / potassium carbonate / tetrahydrofuran; H₂O / 16 h / 85 °C

With pyridine; dmap; potassium carbonate; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/ol060101n

upstream raw materials:

t-butylsulfonamide

2-(1,1-diphenylbut-3-enyl)oxirane

Downstream raw materials:

1-(tert-butylsulfonyl)-2-(1,1-diphenylbut-3-enyl)aziridine