7-[5-(2-diethylaminoethoxy)pyridin-2-ylamino]-1-methyl-3-phenyl-1H-[1,6]naphthyridin-2-one

Base Information

Chemical Name:7-[5-(2-diethylaminoethoxy)pyridin-2-ylamino]-1-methyl-3-phenyl-1H-[1,6]naphthyridin-2-one
CAS No.:1588422-00-7
Molecular Formula:C₂₆H₂₉N₅O₂
Molecular Weight:443.549
Hs Code.:

Synonyms:7-[5-(2-diethylaminoethoxy)pyridin-2-ylamino]-1-methyl-3-phenyl-1H-[1,6]naphthyridin-2-one

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Chemical Property of 7-[5-(2-diethylaminoethoxy)pyridin-2-ylamino]-1-methyl-3-phenyl-1H-[1,6]naphthyridin-2-one

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Technology Process of 7-[5-(2-diethylaminoethoxy)pyridin-2-ylamino]-1-methyl-3-phenyl-1H-[1,6]naphthyridin-2-one

There total 12 articles about 7-[5-(2-diethylaminoethoxy)pyridin-2-ylamino]-1-methyl-3-phenyl-1H-[1,6]naphthyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.3%

: 1588423-44-2
7-chloro-1-methyl-3-phenyl-1,6-naphthyridin-2-(1H)-one

: 1250588-98-7
5-(2-diethylaminoethoxy)pyridin-2-ylamine

: 1588422-00-7
7-[5-(2-diethylaminoethoxy)pyridin-2-ylamino]-1-methyl-3-phenyl-1H-[1,6]naphthyridin-2-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; XPhos; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 846036-96-2
(4-amino-6-chloropyridin-3-yl)methanol

: 1588422-00-7
7-[5-(2-diethylaminoethoxy)pyridin-2-ylamino]-1-methyl-3-phenyl-1H-[1,6]naphthyridin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: manganese(IV) oxide / tetrahydrofuran / 5 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 16 h / 20 °C

4.1: sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

With manganese(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; potassium carbonate; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1588422-00-7
7-[5-(2-diethylaminoethoxy)pyridin-2-ylamino]-1-methyl-3-phenyl-1H-[1,6]naphthyridin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / acetonitrile / 16.5 h / 0 - 20 °C

2.1: trifluoroacetic acid / 16 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

4.1: manganese(IV) oxide / tetrahydrofuran / 5 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

6.2: 16 h / 20 °C

7.1: sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

With manganese(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;