1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol

Base Information

Chemical Name:1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol
CAS No.:820969-82-2
Molecular Formula:C₂₆H₂₅Cl₂F₂NO
Molecular Weight:476.393
Hs Code.:

Synonyms:1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol

Chemical Property:

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Technology Process of 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol

There total 1 articles about 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 820969-80-0
1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)acetone

: 676-58-4
methylmagnesium chloride

: 820969-82-2
1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol

Guidance literature:: In tetrahydrofuran; at -78 - 0 ℃; for 3h;

Reference yield:

: 820969-82-2
1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol

: 820970-76-1
1-[bis(4-chlorophenyl)methyl]-3-[1-(3,5-difluorophenyl)-2-methylprop-1-en-1-yl]azetidine

Guidance literature:: 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol; With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃; for 2h;

With sodium hydroxide; sodium hydrogencarbonate; In diethyl ether; pH=8 - 9;

Reference yield:

: 820969-82-2
1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol

: 820970-79-4
1-[bis(4-chlorophenyl)methyl]-3-[(1S)-1-(3,5-difluorophenyl)-2-fluoro-2-methylpropyl]azetidine

Guidance literature:: 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2-methylpropan-2-ol; With pyridine hydrogenfluoride; In dichloromethane; at 42 ℃; for 9h;

With sodium hydroxide; sodium hydrogencarbonate; In dichloromethane; pH=8 - 9;