N-Cyclopropyl-4-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine

Base Information

Chemical Name:N-Cyclopropyl-4-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine
CAS No.:401816-50-0
Molecular Formula:C₂₁H₁₅F₄N₅
Molecular Weight:413.377
Hs Code.:

Synonyms:N-Cyclopropyl-4-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine

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Chemical Property of N-Cyclopropyl-4-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine

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Technology Process of N-Cyclopropyl-4-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine

There total 9 articles about N-Cyclopropyl-4-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 401816-47-5
2-(4-fluorophenyl)-3-(3-(dimethylamino)-2-propenoyl)-6-trifluoromethylpyrazolo[1,5-a]pyridine

: 168627-33-6
N-cyclopropylguanidine

: 401816-50-0
N-Cyclopropyl-4-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 21h;
DOI:10.1021/ol0519745

Reference yield:

: 372122-55-9
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

: 401816-50-0
N-Cyclopropyl-4-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / H₂SO₄ / 1 h / Heating

2: 73 percent / 17 h / Heating

3: K₂CO₃ / dimethylformamide / 21 h / 100 °C

With sulfuric acid; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/ol0519745

Reference yield:

: 401816-45-3
3-(4-fluorophenyl)-2-(2-(5-trifluoromethyl)pyridyl)-2H-azirine

: 401816-50-0
N-Cyclopropyl-4-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / various solvent(s) / 10 h / 200 °C

2: 99 percent / H₂SO₄ / 1 h / Heating

3: 73 percent / 17 h / Heating

4: K₂CO₃ / dimethylformamide / 21 h / 100 °C

With sulfuric acid; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/ol0519745