5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine

Base Information

• Chemical Name: 5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine
• CAS No.: 1203603-91-1
• Molecular Formula: C₁₈H₁₃Cl₂N₅OS
• Molecular Weight: 418.306

Synonyms:5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine

Chemical Property of 5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine

Chemical Property:

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Technology Process of 5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine

There total 8 articles about 5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(5-methoxy-1,3-benzothiazol-2-yl)methylamine (933738-01-3) + 3-chloro-5-(2,6-dichlorophenyl)-1,2,4-triazine (1203605-10-0) → 5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine (1203603-91-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; Inert atmosphere; Reflux;

Reference yield:

3-chloro-5-(2,6-dichlorophenyl)-1,2,4-triazine (1203605-10-0) + (5-methoxybenzothiazol-2-yl)methylamine hydrogen chloride (1204196-92-8) → 5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine (1203603-91-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 - 85 ℃; Inert atmosphere;

DOI:10.1021/jm301499r

Reference yield:

5-methoxybenzothiazole-2-carboxaldehyde (854059-90-8) → 5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine (1203603-91-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium methylate; hydroxylamine hydrochloride / ethanol / 20 °C / Inert atmosphere

2.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 85 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; acetonitrile;

DOI:10.1021/jm301499r

upstream raw materials:

(5-methoxy-1,3-benzothiazol-2-yl)methylamine

3-chloro-5-(2,6-dichlorophenyl)-1,2,4-triazine

5-methoxybenzothiazole-2-carboxaldehyde

5-methoxy-1,3-benzothiazole-2-carbaldehyde oxime

Downstream raw materials:

2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol

2-{[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetamide

ethyl {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetate

2-(2-{[5-(2,6-dichlorophenyl)[1,2,4]triazin-3-ylamino]methyl}benzothiazol-5-yloxy)ethanol

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