2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol

Base Information

Chemical Name:2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol
CAS No.:1203605-13-3
Molecular Formula:C₁₇H₁₁Cl₂N₅OS
Molecular Weight:404.279
Hs Code.:

Synonyms:2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol

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Chemical Property of 2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol

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Technology Process of 2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol

There total 9 articles about 2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1203603-91-1
5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine

: 1203605-13-3
2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol

Guidance literature:: 5-(2,6-dichlorophenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine; With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With methanol; In dichloromethane; at 0 - 50 ℃;

Reference yield:

: 854059-90-8
5-methoxybenzothiazole-2-carboxaldehyde

: 1203605-13-3
2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate; hydroxylamine hydrochloride / ethanol / 20 °C / Inert atmosphere

2.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 85 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 18 h / -78 - 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium methylate; boron tribromide; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm301499r

Reference yield:

: 1203605-11-1
5-methoxy-1,3-benzothiazole-2-carbaldehyde oxime

: 1203605-13-3
2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 85 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 18 h / -78 - 20 °C / Inert atmosphere

With boron tribromide; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; acetonitrile;
DOI:10.1021/jm301499r