ethyl {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetate

Base Information

Chemical Name:ethyl {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetate
CAS No.:1203605-14-4
Molecular Formula:C₂₁H₁₇Cl₂N₅O₃S
Molecular Weight:490.37
Hs Code.:

Synonyms:ethyl {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetate

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Chemical Property of ethyl {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetate

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Technology Process of ethyl {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetate

There total 10 articles about ethyl {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1203605-13-3
2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol

: 105-36-2
ethyl bromoacetate

: 1203605-14-4
ethyl {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetate

Guidance literature:: 2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-ol; With potassium carbonate; In acetone; at 20 ℃; for 0.5h; Inert atmosphere;

ethyl bromoacetate; In acetone; at 60 ℃;

Reference yield:

: 854059-90-8
5-methoxybenzothiazole-2-carboxaldehyde

: 1203605-14-4
ethyl {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate; hydroxylamine hydrochloride / ethanol / 20 °C / Inert atmosphere

2.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 85 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 18 h / -78 - 20 °C / Inert atmosphere

5.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere

5.2: 60 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium methylate; boron tribromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jm301499r

Reference yield:

: 1203605-11-1
5-methoxy-1,3-benzothiazole-2-carbaldehyde oxime

: 1203605-14-4
ethyl {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 85 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 18 h / -78 - 20 °C / Inert atmosphere

4.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere

4.2: 60 °C / Inert atmosphere

With boron tribromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; acetone; acetonitrile;
DOI:10.1021/jm301499r