2-[(4-tert-butylphenyl)ethynyl]-4-chlorophenyl methoxymethyl sulfide

Base Information

Chemical Name:2-[(4-tert-butylphenyl)ethynyl]-4-chlorophenyl methoxymethyl sulfide
CAS No.:1610038-74-8
Molecular Formula:C₂₀H₂₁ClOS
Molecular Weight:344.905
Hs Code.:

Synonyms:2-[(4-tert-butylphenyl)ethynyl]-4-chlorophenyl methoxymethyl sulfide

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Chemical Property of 2-[(4-tert-butylphenyl)ethynyl]-4-chlorophenyl methoxymethyl sulfide

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Technology Process of 2-[(4-tert-butylphenyl)ethynyl]-4-chlorophenyl methoxymethyl sulfide

There total 2 articles about 2-[(4-tert-butylphenyl)ethynyl]-4-chlorophenyl methoxymethyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 772-38-3
4-tert-Butylphenylacetylene

: 1610038-81-7
4-chloro-2-iodophenyl methoxymethyl sulfide

: 1610038-74-8
2-[(4-tert-butylphenyl)ethynyl]-4-chlorophenyl methoxymethyl sulfide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1039/c4ob00299g

Reference yield:

: 63069-48-7
p-chloro-o-iodoaniline

: 1610038-74-8
2-[(4-tert-butylphenyl)ethynyl]-4-chlorophenyl methoxymethyl sulfide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrafluoroboric acid; isopentyl nitrite / ethanol; water / 0.33 h / 0 °C

1.2: 1.33 h / -40 - 0 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 2.5 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrafluoroboric acid; triethylamine; isopentyl nitrite; In ethanol; water; 2.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4ob00299g