(2S)-2-benzyl 1-tert-butyl 5-methoxypyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2S)-2-benzyl 1-tert-butyl 5-methoxypyrrolidine-1,2-dicarboxylate
CAS No.:331949-31-6
Molecular Formula:C₁₈H₂₅NO₅
Molecular Weight:335.4
Hs Code.:
European Community (EC) Number:608-842-6
DSSTox Substance ID:DTXSID401130868
Nikkaji Number:J1.618.575B

Synonyms:SCHEMBL1300327;BCPUNMKJXAAGNB-MLCCFXAWSA-N;DTXSID401130868;(2S)-2-benzyl 1-tert-butyl 5-methoxypyrrolidine-1,2-dicarboxylate;331949-31-6;1-(1,1-Dimethylethyl) 2-(phenylmethyl) (2S)-5-methoxy-1,2-pyrrolidinedicarboxylate

Suppliers and Price of (2S)-2-benzyl 1-tert-butyl 5-methoxypyrrolidine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (2S)-2-benzyl 1-tert-butyl 5-methoxypyrrolidine-1,2-dicarboxylate

Chemical Property:

Vapor Pressure:2.23E-07mmHg at 25°C
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:335.17327290
Heavy Atom Count:24
Complexity:439

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1C(CCC1OC)C(=O)OCC2=CC=CC=C2
Isomeric SMILES:CC(C)(C)OC(=O)N1[C@@H](CCC1OC)C(=O)OCC2=CC=CC=C2

Technology Process of (2S)-2-benzyl 1-tert-butyl 5-methoxypyrrolidine-1,2-dicarboxylate

There total 13 articles about (2S)-2-benzyl 1-tert-butyl 5-methoxypyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 67-56-1
methanol

: 331949-29-2
benzyl (2S)-N-tert-butoxycarbonyl-5-hydroxypyrrolidine-2-carboxylate

: 331949-31-6
benzyl (2S)-N-tert-butoxycarbonyl-5-methoxypyrrolidine-2-carboxylate

Guidance literature:: With toluene-4-sulfonic acid;
DOI:10.1016/S0040-4039(02)00574-9

Reference yield: 95.0%

: 67-56-1
methanol

: 113400-36-5,400626-71-3
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

: 331949-31-6
benzyl (2S)-N-tert-butoxycarbonyl-5-methoxypyrrolidine-2-carboxylate

Guidance literature:: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate; With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃;

methanol; With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; Further stages.;
DOI:10.1021/ja016403w

Reference yield:

: 94885-52-6
benzyl (L)-pyroglutamate

: 331949-31-6
benzyl (2S)-N-tert-butoxycarbonyl-5-methoxypyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 37.5 g / 4-dimethylaminopyridine / acetonitrile / 3 h / 25 °C

2: 88 percent / LiEt₃BH / tetrahydrofuran / 2 h / -78 °C

3: 98 percent / p-toluenesulfonic acid / 5 h / 25 °C

With dmap; lithium triethylborohydride; toluene-4-sulfonic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol049665m