methyl 3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene-1-carboxylate

Base Information

• Chemical Name: methyl 3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene-1-carboxylate
• CAS No.: 129648-81-3
• Molecular Formula: C₂₅H₂₉NO₄S
• Molecular Weight: 439.576

Synonyms:methyl 3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene-1-carboxylate

Chemical Property of methyl 3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene-1-carboxylate

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Technology Process of methyl 3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene-1-carboxylate

There total 6 articles about methyl 3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.2%

benzenesulfonyl chloride (98-09-9) + 6-Isopropyl-3-(4-amino)butyl-azulene-1-carboxylic acid methyl ester (135717-53-2) → methyl 3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene-1-carboxylate (129648-81-3)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone;

Reference yield:

methyl 6-isopropyl-3-(4-hydroxybutyl)azulene-1-carboxylate (129648-77-7) → methyl 3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene-1-carboxylate (129648-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 96.8 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 12 h / Ambient temperature

2: hydrazine hydrate / ethanol / 2 h / Heating

3: aq. NaHCO₃ / acetone / 0.5 h / 0 °C

With sodium hydrogencarbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; acetone;

DOI:10.1021/jm00059a001

Reference yield:

methyl 6-isopropyl-2-oxo-2H-cycloheptafuran-3-carboxylate (106021-18-5) → methyl 3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene-1-carboxylate (129648-81-3)

Guidance literature:

Multi-step reaction with 5 steps

1: morpholine / ethanol / Heating

2: AlCl₃ / various solvent(s) / 0 °C

3: 96.8 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 12 h / Ambient temperature

4: hydrazine hydrate / ethanol / 2 h / Heating

5: aq. NaHCO₃ / acetone / 0.5 h / 0 °C

With morpholine; aluminium trichloride; sodium hydrogencarbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; acetone;

DOI:10.1021/jm00059a001

upstream raw materials:

benzenesulfonamide

benzenesulfonyl chloride

6-Isopropyl-3-(4-amino)butyl-azulene-1-carboxylic acid methyl ester

methyl 6-isopropyl-2-oxo-2H-cycloheptafuran-3-carboxylate

Downstream raw materials:

N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide

1-(cyanomethyl)-3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene

[3-(4-Benzenesulfonylamino-butyl)-6-isopropyl-azulen-1-yl]-acetic acid

(E)-3-{4-[(phenylsulfonyl)amino]butyl}-6-isopropylazulene-1-acrylic acid

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