N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide

Base Information

• Chemical Name: N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide
• CAS No.: 129648-99-3
• Molecular Formula: C₂₆H₃₄N₂O₂S
• Molecular Weight: 438.634
• Mol file: 129648-99-3.mol

Synonyms:N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide

Chemical Property of N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide

There total 9 articles about N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis-(dimethylamino)methane (51-80-9) + 1-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene (129648-91-5) → N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide (129648-99-3)

Guidance literature:

With formaldehyd; In acetic acid;

DOI:10.1021/jm00171a004

Reference yield:

methyl 6-isopropyl-3-(4-hydroxybutyl)azulene-1-carboxylate (129648-77-7) → N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide (129648-99-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 96.8 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 12 h / Ambient temperature

2: hydrazine hydrate / ethanol / 2 h / Heating

3: aq. NaHCO₃ / acetone / 0.5 h / 0 °C

4: 93.1 percent / phosphoric acid / 0.33 h / 120 °C

5: paraformaldehyde, AcOH / CH₂Cl₂ / 1 h / 0 °C

With formaldehyd; phosphoric acid; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; acetone;

DOI:10.1021/jm00059a001

Reference yield:

3-(4-Benzyloxy-butyl)-6-isopropyl-azulene-1-carboxylic acid methyl ester (129648-73-3) → N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide (129648-99-3)

Guidance literature:

Multi-step reaction with 6 steps

1: AlCl₃ / various solvent(s) / 0 °C

2: 96.8 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 12 h / Ambient temperature

3: hydrazine hydrate / ethanol / 2 h / Heating

4: aq. NaHCO₃ / acetone / 0.5 h / 0 °C

5: 93.1 percent / phosphoric acid / 0.33 h / 120 °C

6: paraformaldehyde, AcOH / CH₂Cl₂ / 1 h / 0 °C

With formaldehyd; aluminium trichloride; phosphoric acid; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; acetone;

DOI:10.1021/jm00059a001

upstream raw materials:

bis-(dimethylamino)methane

1-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene

methyl 6-isopropyl-2-oxo-2H-cycloheptafuran-3-carboxylate

methyl 6-isopropyl-3-(4-hydroxybutyl)azulene-1-carboxylate

Downstream raw materials:

1-(cyanomethyl)-3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene

[3-(4-Benzenesulfonylamino-butyl)-6-isopropyl-azulen-1-yl]-acetic acid