(4S)-4-N-tert-butoxycarbonylamino-5-{[2-(N-tert-butoxycarbonylaminoethyl)benzoyloxyamino]-pentyl}-N'-nitroguanidine

Base Information

Chemical Name:(4S)-4-N-tert-butoxycarbonylamino-5-{[2-(N-tert-butoxycarbonylaminoethyl)benzoyloxyamino]-pentyl}-N'-nitroguanidine
CAS No.:939429-23-9
Molecular Formula:C₂₅H₄₁N₇O₈
Molecular Weight:567.643
Hs Code.:

Synonyms:(4S)-4-N-tert-butoxycarbonylamino-5-{[2-(N-tert-butoxycarbonylaminoethyl)benzoyloxyamino]-pentyl}-N'-nitroguanidine

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Chemical Property of (4S)-4-N-tert-butoxycarbonylamino-5-{[2-(N-tert-butoxycarbonylaminoethyl)benzoyloxyamino]-pentyl}-N'-nitroguanidine

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Technology Process of (4S)-4-N-tert-butoxycarbonylamino-5-{[2-(N-tert-butoxycarbonylaminoethyl)benzoyloxyamino]-pentyl}-N'-nitroguanidine

There total 4 articles about (4S)-4-N-tert-butoxycarbonylamino-5-{[2-(N-tert-butoxycarbonylaminoethyl)benzoyloxyamino]-pentyl}-N'-nitroguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 357966-04-2
(4S)-4-N-tert-butoxycarbonylamino-5-(2-[N-tert-butoxycarbonylaminoethyl]aminopentyl)-N'-nitroguanidine

: 94-36-0
dibenzoyl peroxide

: 939429-23-9
(4S)-4-N-tert-butoxycarbonylamino-5-{[2-(N-tert-butoxycarbonylaminoethyl)benzoyloxyamino]-pentyl}-N'-nitroguanidine

Guidance literature:: With disodium hydrogenphosphate; In tetrahydrofuran; diethyl ether; at 70 ℃; for 24h;
DOI:10.1021/jm061305c

Reference yield:

: 939429-22-8
N^α-(tert-butoxycarbonyl)-L-nitroarginine 2-(N-tert-butoxycarbonylaminoethyl)amide

: 939429-23-9
(4S)-4-N-tert-butoxycarbonylamino-5-{[2-(N-tert-butoxycarbonylaminoethyl)benzoyloxyamino]-pentyl}-N'-nitroguanidine

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / borane / tetrahydrofuran / 10 h / 0 °C

2: 68 percent / disodium hydrogen phosphate / diethyl ether; tetrahydrofuran / 24 h / 70 °C

With disodium hydrogenphosphate; borane; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm061305c

Reference yield:

: 57260-73-8
N-BOC-1,2-diaminoethane

: 939429-23-9
(4S)-4-N-tert-butoxycarbonylamino-5-{[2-(N-tert-butoxycarbonylaminoethyl)benzoyloxyamino]-pentyl}-N'-nitroguanidine

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / HBTU; HOBt; DIEA / dimethylformamide; CH₂Cl₂ / 2 h / 20 °C

2: 56 percent / borane / tetrahydrofuran / 10 h / 0 °C

3: 68 percent / disodium hydrogen phosphate / diethyl ether; tetrahydrofuran / 24 h / 70 °C

With disodium hydrogenphosphate; borane; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm061305c