4-hydroxy-5-(hydroxypropyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Base Information

Chemical Name:4-hydroxy-5-(hydroxypropyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran
CAS No.:120034-19-7
Molecular Formula:C₂₀H₂₁ClO₄
Molecular Weight:360.837
Hs Code.:

Synonyms:4-hydroxy-5-(hydroxypropyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

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Chemical Property of 4-hydroxy-5-(hydroxypropyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Chemical Property:

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Technology Process of 4-hydroxy-5-(hydroxypropyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

There total 10 articles about 4-hydroxy-5-(hydroxypropyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: silylated phenol alcohol

: 429-41-4
tetrabutyl ammonium fluoride

: 18162-48-6
tert-butyldimethylsilyl chloride

: 120034-18-6
5-allyl-4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

: 120034-19-7
4-hydroxy-5-(hydroxypropyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Guidance literature:: With hydrogenchloride; 2-(Dimethylamino)pyridine; trimethylamine-N-oxide; borane; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 120034-24-4
3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol

: 120034-19-7
4-hydroxy-5-(hydroxypropyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; Yield given;
DOI:10.1021/jm00126a008

Reference yield:

: 120034-10-8
3-chloro-5-tert-butyl-2,6-dihydroxyacetophenone

: 120034-19-7
4-hydroxy-5-(hydroxypropyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Guidance literature:: Multi-step reaction with 8 steps

2: 81 percent / ZnI₂, NaCNBH₄ / 1,2-dichloro-ethane / 6 h / Heating

3: 58 percent / AlCl₃ / CH₂Cl₂; various solvent(s) / 1 h / 0 °C

4: 1.94 g / K₂CO₃ / acetone / 20 h / Heating

5: 1.5 g / various solvent(s) / 6 h / Heating

6: 410 mg / Et₃N, (dimethylamino)pyridine / CH₂Cl₂ / 20 h / Ambient temperature

7: 1.) BH₃, 2.) trimethylamine N-oxide / 1.a) THF, -78 deg C, 1 h, b) r.t., 1 h, 2.) reflux, 3 h

8: tetra-n-butylammonium fluoride / tetrahydrofuran

With dmap; aluminium trichloride; trimethylamine-N-oxide; borane; tetrabutyl ammonium fluoride; sodium cyanoborohydride; potassium carbonate; triethylamine; zinc(II) iodide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; acetone;
DOI:10.1021/jm00126a008