1-Cyclopropyl-6-fluoro-8-Methoxy-4-oxo-7-(piperazin-1-yl)1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:1-Cyclopropyl-6-fluoro-8-Methoxy-4-oxo-7-(piperazin-1-yl)1,4-dihydroquinoline-3-carboxylic acid
CAS No.:112811-57-1
Molecular Formula:C₁₈H₂₀FN₃O₄
Molecular Weight:361.373
Hs Code.:2933990090
Mol file:112811-57-1.mol

Synonyms:AM 1147; PD135042

Suppliers and Price of 1-Cyclopropyl-6-fluoro-8-Methoxy-4-oxo-7-(piperazin-1-yl)1,4-dihydroquinoline-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-DesmethylGatifloxacin
250mg
$ 1320.00

Chemenu
1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylicacid 95%
1g
$ 281.00

Chemenu
1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylicacid 95%
5g
$ 842.00

American Custom Chemicals Corporation
3-DESMETHYL GATIFLOXACIN 95.00%
5MG
$ 504.49

American Custom Chemicals Corporation
1-CYCLOPROPYL-6-FLUORO-8-METHOXY-4-OXO-7-(PIPERAZIN-1-YL)-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 95.00%
5MG
$ 501.49

Activate Scientific
DesmethylGatifloxacin 95%
250 mg
$ 211.00

Activate Scientific
DesmethylGatifloxacin 95%
1 g
$ 433.00

Total 20 raw suppliers

Chemical Property of 1-Cyclopropyl-6-fluoro-8-Methoxy-4-oxo-7-(piperazin-1-yl)1,4-dihydroquinoline-3-carboxylic acid

Chemical Property:

Vapor Pressure:8.51E-16mmHg at 25°C
Melting Point:197 °C(Solv: chloroform (67-66-3); ethanol (64-17-5))
Boiling Point:611.3°C at 760 mmHg
PKA:6.43±0.50(Predicted)
Flash Point:323.5°C
PSA：83.80000
Density:1.441g/cm³
LogP:1.98570
Storage Temp.:2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

3-DesmethylGatifloxacin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-Desmethyl Gatifloxacin is an impurity of Gatifloxacin (G250000).

Technology Process of 1-Cyclopropyl-6-fluoro-8-Methoxy-4-oxo-7-(piperazin-1-yl)1,4-dihydroquinoline-3-carboxylic acid

There total 4 articles about 1-Cyclopropyl-6-fluoro-8-Methoxy-4-oxo-7-(piperazin-1-yl)1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 110-85-0
piperazine

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 112811-57-1
8-methoxyciprofloxacin

Guidance literature:: With triethylamine; In acetonitrile; for 144h; Reflux;
DOI:10.1016/j.bmcl.2021.128450

Reference yield:

: 124-41-4
sodium methylate

: 94242-53-2
1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

: 112811-57-1
8-methoxyciprofloxacin

Guidance literature:: With sodium methylate; In ethanol; at 140 - 150 ℃; for 72.5h;

Reference yield:

: 110-85-0
piperazine

: 847233-56-1
1-cyclopropyl-1,4-dihydro-6,7-difluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid difluoroborate ester

: 112811-57-1
8-methoxyciprofloxacin

Guidance literature:: With triethylamine; Yield given. Multistep reaction; 1.) CH₃CN, 50 deg C, 18 h, 2.) CH₃CN, reflux, 18 h;
DOI:10.1021/jm00022a013