Technology Process of 1-phenylethynyl-2-(phenylsulfonylmethyl)benzene
There total 10 articles about 1-phenylethynyl-2-(phenylsulfonylmethyl)benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
at 55 ℃;
for 2h;
DOI:10.1021/jo0620563
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: TMSOTf
2.1: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: tetrahydrofuran; hexane / 1 h / -78 °C
3.1: tetrahydrofuran; hexane / 2 h
4.1: t-BuOK / tetrahydrofuran; hexane / 3.67 h / 0 - 20 °C
5.1: 98 percent / p-TsOH; H2O / acetone / 16 h / 40 °C
6.1: NaBH4
7.1: PBr3
8.1: dimethylformamide
With
sodium tetrahydroborate; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; water; phosphorus tribromide; toluene-4-sulfonic acid;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone;
1.1: Etherification / 2.1: Metallation / 2.2: Addition / 3.1: Substitution / 4.1: Elimination / 5.1: Hydrolysis / 6.1: Reduction / 7.1: Substitution / 8.1: Substitution;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: tetrahydrofuran; hexane / 1 h / -78 °C
2.1: tetrahydrofuran; hexane / 2 h
3.1: t-BuOK / tetrahydrofuran; hexane / 3.67 h / 0 - 20 °C
4.1: 98 percent / p-TsOH; H2O / acetone / 16 h / 40 °C
5.1: NaBH4
6.1: PBr3
7.1: dimethylformamide
With
sodium tetrahydroborate; n-butyllithium; potassium tert-butylate; water; phosphorus tribromide; toluene-4-sulfonic acid;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone;
1.1: Metallation / 1.2: Addition / 2.1: Substitution / 3.1: Elimination / 4.1: Hydrolysis / 5.1: Reduction / 6.1: Substitution / 7.1: Substitution;
