1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propoxy)-6-methoxyquinazolin-4-yloxy)phenyl)urea

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Chemical Name:1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propoxy)-6-methoxyquinazolin-4-yloxy)phenyl)urea
CAS No.:1188907-09-6
Molecular Formula:C₃₂H₄₁N₇O₆
Molecular Weight:619.721
Hs Code.:

Synonyms:1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propoxy)-6-methoxyquinazolin-4-yloxy)phenyl)urea

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Chemical Property of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propoxy)-6-methoxyquinazolin-4-yloxy)phenyl)urea

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Technology Process of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propoxy)-6-methoxyquinazolin-4-yloxy)phenyl)urea

There total 10 articles about 1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propoxy)-6-methoxyquinazolin-4-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1188907-05-2
1-(5-tert-butyl-isoxazol-3-yl)-3-{3-[7-(3-chloro-propoxy)-6-methoxy-quinazolin-4-yloxy]-phenyl}-urea

: 1188907-09-6
1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propoxy)-6-methoxyquinazolin-4-yloxy)phenyl)urea

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃; for 48h;

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 1188907-09-6
1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propoxy)-6-methoxyquinazolin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

2: nitric acid; acetic anhydride / water; acetic acid / 0 - 50 °C

3: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 12 h

4: ethanol / 12 h / 140 °C

5: trichlorophosphate / toluene / 5 h / 125 °C

6: caesium carbonate / tetrahydrofuran / 12 h / 50 °C

7: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 60 °C

With hydrogen; nitric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 111627-40-8
methyl 4-(3-chloropropoxy)-3-methoxybenzoate

: 1188907-09-6
1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propoxy)-6-methoxyquinazolin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid; acetic anhydride / water; acetic acid / 0 - 50 °C

2: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 12 h

3: ethanol / 12 h / 140 °C

4: trichlorophosphate / toluene / 5 h / 125 °C

5: caesium carbonate / tetrahydrofuran / 12 h / 50 °C

6: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 60 °C

With hydrogen; nitric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene;