3-[4-(2-methoxyethoxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride

Base Information

Chemical Name:3-[4-(2-methoxyethoxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride
CAS No.:1192189-63-1
Molecular Formula:C₁₉H₂₉N₃O₅*ClH
Molecular Weight:415.917
Hs Code.:

Synonyms:3-[4-(2-methoxyethoxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride

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Chemical Property of 3-[4-(2-methoxyethoxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride

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Technology Process of 3-[4-(2-methoxyethoxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride

There total 4 articles about 3-[4-(2-methoxyethoxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 1192189-63-1
3-[4-(2-methoxyethoxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.13 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: lithium hydroxide; water / ethanol / 18 h / 80 °C / Inert atmosphere

3.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / Inert atmosphere

3.2: 18 h / Inert atmosphere

4.1: hydrogenchloride; methanol / 1,4-dioxane / 0.5 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; methanol; oxalyl dichloride; water; N,N-dimethyl-formamide; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/ml500367g

Reference yield:

: 1192189-60-8
1-tert-butyl 4-ethyl 4-[(2-methoxyethoxy)methyl]piperidine-1,4-dicarboxylate

: 1192189-63-1
3-[4-(2-methoxyethoxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / ethanol / 18 h / 80 °C / Inert atmosphere

2.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / Inert atmosphere

2.2: 18 h / Inert atmosphere

3.1: hydrogenchloride; methanol / 1,4-dioxane / 0.5 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; methanol; oxalyl dichloride; water; N,N-dimethyl-formamide; lithium hydroxide; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/ml500367g

Reference yield:

: 1192189-61-9
1-(tert-butoxycarbonyl)-4-(2-methoxyethoxy)piperidine-4-carboxylic acid

: 1192189-63-1
3-[4-(2-methoxyethoxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / Inert atmosphere

1.2: 18 h / Inert atmosphere

2.1: hydrogenchloride; methanol / 1,4-dioxane / 0.5 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; methanol; oxalyl dichloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ml500367g