N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)acrylamide

Base Information

Chemical Name:N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)acrylamide
CAS No.:1407520-45-9
Molecular Formula:C₂₉H₃₇ClN₇O₄P
Molecular Weight:614.084
Hs Code.:

Synonyms:N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)acrylamide

Suppliers and Price of N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)acrylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)acrylamide

There total 9 articles about N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1407520-44-8
C₂₆H₃₅ClN₇O₃P

: 814-68-6,25189-84-8
acryloyl chloride

: 1407520-45-9
N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 450-91-9
4-fluoro-2-methoxyaniline

: 1407520-45-9
N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; guanidine nitrate / 0.5 h / Cooling with ice

2.1: trifluoroacetic acid / iso-butanol / 100 °C / Sealed tube

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 20 °C

3.2: 0.42 h / 67 °C / Sealed tube

4.1: ammonium chloride; zinc / water; acetone / 0.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

With sulfuric acid; guanidine nitrate; sodium hydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; water; acetone; iso-butanol; mineral oil;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1407520-45-9
N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium chloride; zinc / water; acetone / 0 - 20 °C

2.1: sulfuric acid; guanidine nitrate / 0.5 h / Cooling with ice

3.1: trifluoroacetic acid / iso-butanol / 100 °C / Sealed tube

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 20 °C

4.2: 0.42 h / 67 °C / Sealed tube

5.1: ammonium chloride; zinc / water; acetone / 0.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

With sulfuric acid; guanidine nitrate; sodium hydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; water; acetone; iso-butanol; mineral oil;