methyl 5-(2-chlorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylate

Base Information

Chemical Name:methyl 5-(2-chlorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylate
CAS No.:1207203-78-8
Molecular Formula:C₂₆H₂₇ClO₅S
Molecular Weight:487.016
Hs Code.:

Synonyms:methyl 5-(2-chlorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylate

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Chemical Property of methyl 5-(2-chlorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylate

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Technology Process of methyl 5-(2-chlorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylate

There total 7 articles about methyl 5-(2-chlorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33821-94-2
3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide

: 1207203-77-7
Methyl 5-(2-chlorophenyl)-4-(4-hydroxyphenyl)thiophene-2-carboxylate

: 1207203-78-8
methyl 5-(2-chlorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 7h;

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 1207203-78-8
methyl 5-(2-chlorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -60 °C / Inert atmosphere

1.2: 0.75 h / -60 - 0 °C / Inert atmosphere

1.3: Cooling with ice

2.1: tetrahydrofuran / 3 h / Reflux

3.1: trichlorophosphate / dichloromethane / 45 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 60 °C

5.1: boron tribromide / dichloromethane / -50 - 20 °C

6.1: N,N-dimethyl-formamide / 7 h / 60 °C

With sodium hexamethyldisilazane; boron tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 610-96-8
methyl chlorobenzoate

: 1207203-78-8
methyl 5-(2-chlorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -60 °C / Inert atmosphere

1.2: 0.75 h / -60 - 0 °C / Inert atmosphere

1.3: Cooling with ice

2.1: tetrahydrofuran / 3 h / Reflux

3.1: trichlorophosphate / dichloromethane / 45 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 60 °C

5.1: boron tribromide / dichloromethane / -50 - 20 °C

6.1: N,N-dimethyl-formamide / 7 h / 60 °C

With sodium hexamethyldisilazane; boron tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;